{"id":3180,"date":"2021-02-16T13:22:34","date_gmt":"2021-02-16T13:22:34","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/self-administration\/"},"modified":"2025-11-26T14:19:05","modified_gmt":"2025-11-26T14:19:05","slug":"self-administration","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/self-administration\/","title":{"rendered":"Self-administration"},"content":{"rendered":"<p>Intravenous self-administration in rats is an extremely reliable predictor of the risk of abuse by humans and this test forms an integral component of the non-clinical package that is part of the regulatory evaluation for all CNS active drugs.<\/p>\n<ul>\n<li>We provide intravenous self-administration testing in rats for evaluation of the reinforcing potential of drugs. Experience with a wide range of drugs including stimulants, opioids, nicotine, MDMA and other entactogens, NMDA antagonists, cannabinoids, and benzodiazepines.<\/li>\n<li>Fixed and progressive ratio schedules of drug reinforcement<\/li>\n<li>\u2018Break-point\u2019 analysis to quantify the relative reinforcing effects of drugs<\/li>\n<\/ul>\n<p>In this model rats are trained to self-administer a known drug of abuse and the ability of the test compound to maintain responding is subsequently determined. Selection of an appropriate training drug is a critical aspect of the study design and is something Sygnature experts are well-positioned to advise on.<\/p>\n<p><strong>Heroin or cocaine maintain self-administration under a fixed-ratio schedule of reinforcement in rats<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10364\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Heroin-or-cocaine-maintain-self-administration-under-a-fixed-ratio-schedule-of-reinforcement-in-rats.png\" alt=\"\" \/><\/p>\n<p><strong>Assessment of reinforcing efficacy using a progressive-ratio schedule in rats<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10365\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Assessment-of-reinforcing-efficacy-using-a-progressive-ratio-schedule-in-rats.png\" alt=\"\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":3181,"template":"","category":[1],"resource_tag":[],"class_list":["post-3180","technical-note","type-technical-note","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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