{"id":3157,"date":"2021-02-16T13:12:05","date_gmt":"2021-02-16T13:12:05","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/substance-use-disorders-withdrawal-alleviation\/"},"modified":"2025-11-26T14:18:55","modified_gmt":"2025-11-26T14:18:55","slug":"substance-use-disorders-withdrawal-alleviation","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/substance-use-disorders-withdrawal-alleviation\/","title":{"rendered":"Substance Use Disorders: Withdrawal alleviation"},"content":{"rendered":"<p>To explore therapeutic interventions targeted at ameliorating withdrawal symptomology, we use a rat model of physical dependence and withdrawal. This model allows us to profile withdrawal symptoms following repeated administration of the drug abuse, and to then explore whether putative therapeutics can reduce this withdrawal syndrome. Test compounds effective in this model may have therapeutic potential for helping drug dependent patients achieve abstinence.<\/p>\n<p><strong>Withdrawal-induced physical dependence can occur following sub-chronic dosing of CNS-active drugs<\/strong><\/p>\n<p>\u00a0<\/p>\n<ul>\n<li>We offer a rat model for assessing physical dependence and withdrawal using a detailed checklist of over 40 different parameters<\/li>\n<li>This model can be used to assess whether novel treatments reduce the withdrawal symptoms associated with drugs of abuse<\/li>\n<li>The example data below show the development of withdrawal symptoms when b.i.d morphine administration was stopped on day 28<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10333\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Withdrawal-induced-physical-dependence-can-occur-following-sub-chronic-dosing-of-CNS-active-drugs.png\" alt=\"\"><\/p>\n<p>We also offer <a href=\"https:\/\/www.sygnaturediscovery.com\/publications\/technical-notes\/substance-use-disorders-cessation-of-drug-self-administration\/\">cessation of drug self-administration<\/a> approach, <a href=\"https:\/\/www.sygnaturediscovery.com\/publications\/technical-notes\/substance-use-disorders-reinstatement-model-of-drug-relapse\/\">reinstatement model of drug relapse<\/a> and <a href=\"https:\/\/www.sygnaturediscovery.com\/publications\/technical-notes\/substance-use-disorders-locomotor-sensitization\/\">locomotor sensitization<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Withdrawal Symptom Relief: Our rat model assesses drug dependence &#038; withdrawal profiles. Explore potential therapeutics now.<\/p>\n","protected":false},"featured_media":3158,"template":"","category":[1],"resource_tag":[],"class_list":["post-3157","technical-note","type-technical-note","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Alleviating Withdrawal in Substance Use Disorders<\/title>\n<meta name=\"description\" content=\"Withdrawal Alleviation: Our rat model assesses drug dependence &amp; withdrawal profiles. Explore potential therapeutics now.\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alleviating Withdrawal in Substance Use Disorders\" \/>\n<meta property=\"og:description\" content=\"Withdrawal Alleviation: Our rat model assesses drug dependence &amp; withdrawal profiles. Explore potential therapeutics now.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/substance-use-disorders-withdrawal-alleviation\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-26T14:18:55+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Withdrawal-induced-physical-dependence-can-occur-following-sub-chronic-dosing-of-CNS-active-drugs.png\" \/>\n\t<meta property=\"og:image:width\" content=\"721\" \/>\n\t<meta property=\"og:image:height\" content=\"310\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/substance-use-disorders-withdrawal-alleviation\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/substance-use-disorders-withdrawal-alleviation\\\/\",\"name\":\"Alleviating Withdrawal in Substance Use Disorders\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/substance-use-disorders-withdrawal-alleviation\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/substance-use-disorders-withdrawal-alleviation\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Withdrawal-induced-physical-dependence-can-occur-following-sub-chronic-dosing-of-CNS-active-drugs.png\",\"datePublished\":\"2021-02-16T13:12:05+00:00\",\"dateModified\":\"2025-11-26T14:18:55+00:00\",\"description\":\"Withdrawal Alleviation: Our rat model assesses drug dependence & withdrawal profiles. 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