{"id":3155,"date":"2021-02-16T13:11:38","date_gmt":"2021-02-16T13:11:38","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/substance-use-disorders-cessation-of-drug-self-administration\/"},"modified":"2025-11-26T14:18:54","modified_gmt":"2025-11-26T14:18:54","slug":"substance-use-disorders-cessation-of-drug-self-administration","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/substance-use-disorders-cessation-of-drug-self-administration\/","title":{"rendered":"Substance Use Disorders: Cessation of drug self-administration"},"content":{"rendered":"

To explore potential therapeutic interventions for achieving abstinence, we can utilise the self-administration model in rats and evaluate whether test compounds reduce drug intake. This model had demonstrated translational value for mechanisms which reduce the reinforcing value of the drug of abuse.<\/p>\n

Progressive ratio schedules and breakpoint analysis can be used to quantify how novel treatments influence the motivation\/persistence of the animal to self-administer known drugs of abuse<\/p>\n

Repeated administration of the opioid agonist buprenorphine reduces the motivation of rats to self-administer remifentanil, using a progressive ratio schedule of reinforcement.<\/strong><\/h2>\n

\"\"<\/p>\n

We also offer withdrawal alleviation<\/a> approach, reinstatement model of drug relapse<\/a> and locomotor sensitization<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":3156,"template":"","category":[1],"resource_tag":[],"class_list":["post-3155","technical-note","type-technical-note","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nDrug Self-Admin Cessation in Substance Use Disorders<\/title>\n<meta name=\"description\" content=\"Substance Use Disorder: Rat self-administration model assesses abstinence therapies, reinforcement reduction, and withdrawal alleviation.\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Drug Self-Admin Cessation in Substance Use Disorders\" \/>\n<meta property=\"og:description\" content=\"Substance Use Disorder: 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