{"id":3147,"date":"2021-02-16T13:08:55","date_gmt":"2021-02-16T13:08:55","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/schizophrenia-psychosis\/"},"modified":"2025-11-26T14:18:52","modified_gmt":"2025-11-26T14:18:52","slug":"schizophrenia-psychosis","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/schizophrenia-psychosis\/","title":{"rendered":"Schizophrenia, Psychosis"},"content":{"rendered":"<p>Sygnature offers a range of assays that can be used to develop compounds to treat schizophrenia and related disorders. Compounds can be evaluated in well-established dopaminergic or hypo-glutamatergic hyperactivity assays, as well as assessment in the conditioned avoidance assay; selective disruption of the conditioned response is a characteristic property of both typical and novel antipsychotic agents.<\/p>\n<p><strong>Amphetamine or PCP induced locomotor activity<\/strong><\/p>\n<ul>\n<li>Antipsychotic drugs reverse the hyperactivity induced by amphetamine or PCP in mice and rats<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>Reversal of PCP-induced hyperactivity in mice by the atypical antipsychotic olanzapine<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10317\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Reversal-of-PCP-induced-hyperactivity-in-mice-by-the-atypical-antipsychotic-olanzapine.png\" alt=\"\"><\/p>\n<p>\u00a0<\/p>\n<p><strong>Conditioned Avoidance Response<\/strong><\/p>\n<ul>\n<li>Typical and novel antipsychotic agents selectively inhibit the conditioned avoidance response in rats without affecting the unconditioned response. The efficacy of a drug to suppress conditioned avoidance responding in rats correlates with its ability to reduce psychosis in man. The conditioned avoidance response test is a crucial model in development of drugs to treat schizophrenia<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>The atypical antipsychotic Olanzapine reduces conditioned avoidance responding in rats<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10318\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-atypical-antipsychotic-Olanzapine-reduces-conditioned-avoidance-responding-in-rats.png\" alt=\"\"> <img decoding=\"async\" class=\"aligncenter size-large wp-image-10319\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-atypical-antipsychotic-Olanzapine-reduces-conditioned-avoidance-responding-in-rats1.png\" alt=\"\"><\/p>\n<p>\u00a0<\/p>\n<p><strong>DOI-induced head twitch in mice<\/strong><\/p>\n<ul>\n<li>Many novel antipsychotic agents inhibit DOI-induced head twitch indicating an interaction with the serotonergic system<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>Inhibition of DOI-induced head twitch in mice by the atypical antipsychotic olanzapine<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10320\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Inhibition-of-DOI-induced-head-twitch-in-mice-by-the-atypical-antipsychotic-olanzapine.png\" alt=\"\"><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Advancing Schizophrenia Treatment with potent assays. Breakthrough compounds and hyperactivity reversal. Discover more.<\/p>\n","protected":false},"featured_media":3148,"template":"","category":[1],"resource_tag":[],"class_list":["post-3147","technical-note","type-technical-note","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Schizophrenia, Psychosis - Technical Notes - Sygnature Discovery<\/title>\n<meta name=\"description\" content=\"Advancing Schizophrenia Treatment with potent assays. Breakthrough compounds and hyperactivity reversal. 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