{"id":3128,"date":"2021-02-16T12:57:57","date_gmt":"2021-02-16T12:57:57","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/zdf-rat-model-of-diabetic-nephropathy\/"},"modified":"2025-11-26T14:18:22","modified_gmt":"2025-11-26T14:18:22","slug":"zdf-rat-model-of-diabetic-nephropathy","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/zdf-rat-model-of-diabetic-nephropathy\/","title":{"rendered":"ZDF Rat Model of Diabetic Nephropathy"},"content":{"rendered":"<p>Zucker diabetic fatty (ZDF-Leprfa\/Crl) rats exhibit obesity, insulin resistance, impaired glucose tolerance, hypertension, and renal and cardiovascular disease due to deficits in leptin signalling. The ZDF rat model develops a phenotype very similar to humans with type 2 diabetes , including the existence of diabetic nephropathy.<strong>\u00a0<\/strong><\/p>\n<p><strong>The progressive diabetes in Zucker diabetic fatty (ZDF-Leprfa\/Crl) rats leads to a decline in renal function.<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10290\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-progressive-diabetes-in-Zucker-diabetic-fatty-ZDF-LeprfaCrl-rats-leads-to-a-decline-in-renal-function.png\" alt=\"\"><\/p>\n<p><strong>ZDF-Lepr fa\/Crl rats show glomerular and tubulointerstitial damage with string hydronephrosis, tubular atrophy\/dilation, hyaline casts and retraction of glomerular tufts<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10291\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Screen-Shot-2021-02-16-at-12.57.26.png\" alt=\"\"><\/p>\n<p><strong>The ZDF rat displays progressive hyperglycaemia and elevated blood HbA1c<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10246\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-ZDF-rat-displays-progressive-hyperglycaemia-and-elevated-blood-HbA1c.png\" alt=\"\"><\/p>\n<p>\u00a0<\/p>\n<p><strong>The ZDF rat displays significantly increased urinary glucose excretion<\/strong><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10247\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-ZDF-rat-displays-significantly-increased-urinary-glucose-excretion.png\" alt=\"\"><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":3129,"template":"","category":[1],"resource_tag":[],"class_list":["post-3128","technical-note","type-technical-note","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - 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