{"id":3120,"date":"2021-02-16T12:49:16","date_gmt":"2021-02-16T12:49:16","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/adriamycin-induced-model-of-focal-segmental-glomerulosclerosis-fsgs-and-fibrosis\/"},"modified":"2025-11-26T14:18:19","modified_gmt":"2025-11-26T14:18:19","slug":"adriamycin-induced-model-of-focal-segmental-glomerulosclerosis-fsgs-and-fibrosis","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/adriamycin-induced-model-of-focal-segmental-glomerulosclerosis-fsgs-and-fibrosis\/","title":{"rendered":"Adriamycin-induced model of focal segmental glomerulosclerosis (FSGS) and fibrosis"},"content":{"rendered":"<p>Focal segmental glomerulosclerosis (FSGS) is one of the most common causes of primary glomerular diseases in adults. FSGS is induced in rodents by administration of adriamycin (anthracycline also called doxorubicin).\u00a0 Structural and functional injury in adriamycin induced nephropathy mimics proteinuric kidney disease in humans.<strong>\u00a0<\/strong><\/p>\n<p>The model is characterised by:<\/p>\n<ul>\n<li>Quick induction of renal injury, it occurs within days of Adriamycin administration<\/li>\n<li>Customisable study design tailored to determine prevention or reversal of phenotype<\/li>\n<li>Prevention and partial reversal of the phenotype has been demonstrated using Enalapril<\/li>\n<\/ul>\n<p><strong>Prevention and partial reversal of the adriamycin-induced phenotype has been demonstrated using Enalapril<\/strong><\/p>\n<p><strong> <img decoding=\"async\" class=\"aligncenter size-full wp-image-10277\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Screen-Shot-2021-02-16-at-12.48.07.png\" alt=\"\" \/><\/strong><\/p>\n<p><strong>Inhibition of TGF<\/strong><strong>\u03b2<\/strong><strong> receptor I prevents fibrosis in the adriamycin-induced nephropathy model<\/strong><\/p>\n<p><strong> <img decoding=\"async\" class=\"aligncenter size-full wp-image-10278\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Inhibition-of-TGF\u03b2-receptor-I-prevents-fibrosis-in-the-adriamycin-induced-nephropathy-model.png\" alt=\"\" \/><\/strong><\/p>\n<p><a href=\"https:\/\/www.sygnaturediscovery.com\/contact\/\">Get in touch<\/a> for more information or <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/in-vivo-pharmacology\/fibrosis-models\/\">browse our models<\/a> of fibrotic diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Explore the Adriamycin-induced Model of Focal Segmental Glomerulosclerosis (FSGS) and Fibrosis. Discover how this rodent model mimics human proteinuric kidney disease, offering quick induction of renal injury and a customizable study design for prevention or reversal of the phenotype. Witness the demonstrated effectiveness of Enalapril in preventing and partially reversing the adriamycin-induced phenotype. Unravel new insights into FSGS research today.<\/p>\n","protected":false},"featured_media":3121,"template":"","category":[1],"resource_tag":[],"class_list":["post-3120","technical-note","type-technical-note","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Adriamycin-induced FSGS Model with Enalapril efficacy<\/title>\n<meta name=\"description\" content=\"Explore the Adriamycin-induced Model of Focal Segmental Glomerulosclerosis (FSGS) and Fibrosis. Discover more.\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adriamycin-induced FSGS Model with Enalapril efficacy\" \/>\n<meta property=\"og:description\" content=\"Explore the Adriamycin-induced Model of Focal Segmental Glomerulosclerosis (FSGS) and Fibrosis. 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