{"id":3114,"date":"2021-02-16T12:43:30","date_gmt":"2021-02-16T12:43:30","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/assessment-of-gastric-emptying-rate-to-explore-mechanisms-of-satiety-and-reduced-food-intake\/"},"modified":"2025-11-26T14:18:17","modified_gmt":"2025-11-26T14:18:17","slug":"assessment-of-gastric-emptying-rate-to-explore-mechanisms-of-satiety-and-reduced-food-intake","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/assessment-of-gastric-emptying-rate-to-explore-mechanisms-of-satiety-and-reduced-food-intake\/","title":{"rendered":"Assessment of gastric emptying rate to explore mechanisms of satiety and reduced food intake"},"content":{"rendered":"<p>The inhibition of gastric emptying has been linked to satiety and reduced food intake. We offer direct (phenol red recovery) and indirect (serum APAP) models of gastric emptying, depending on your project requirements. This allows the ability of drugs to inhibit gastric emptying to be evaluated. Both models have been validated using the clinical opioid agonist loperamide,\u00a0 which decreased gastric emptying compared to control animals.<\/p>\n<p>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-16231 aligncenter\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/semaglutide-graph.png\" alt=\"\" width=\"649\" height=\"459\"><\/p>\n<h4><strong>Loperamide Inhibits gastric emptying in a dose-dependent manner in mice (measured directly using the Phenol Red method)<\/strong><\/h4>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-10267\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Screen-Shot-2021-02-16-at-12.42.56.png\" alt=\"\"><\/p>\n<p><strong>Loperamide Inhibits gastric emptying in a dose-dependent manner in rats (measured indirectly using the serum APAP method)<\/strong><\/p>\n<p><img decoding=\"async\" class=\"size-medium wp-image-16797 aligncenter\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/RS2245_SV.jpg\" alt=\"\"><\/p>\n<h4><\/h4>\n<p>We also provide a solid food model to investigate the ability of drugs to inhibit\u00a0gastric emptying.<\/p>\n<p><a href=\"https:\/\/www.sygnaturediscovery.com\/contact\/\">Get in touch<\/a> for more information or <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/in-vivo-pharmacology\/metabolic-disorder-models\/\">browse our models<\/a> of metabolic disorders.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Explore the mechanisms of satiety and reduced food intake through gastric emptying rate assessment. Our direct and indirect models offer insights into drug effects. Validate with clinical opioid agonist loperamide.<\/p>\n","protected":false},"featured_media":3115,"template":"","category":[1],"resource_tag":[],"class_list":["post-3114","technical-note","type-technical-note","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gastric Emptying &amp; Satiety: Insights - Sygnature Discovery<\/title>\n<meta name=\"description\" content=\"Study satiety mechanisms with gastric emptying rate assessment. Direct &amp; indirect models available. 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