{"id":3105,"date":"2021-02-16T11:02:40","date_gmt":"2021-02-16T11:02:40","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/assessment-of-energy-expenditure\/"},"modified":"2025-11-26T14:18:10","modified_gmt":"2025-11-26T14:18:10","slug":"assessment-of-energy-expenditure","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/assessment-of-energy-expenditure\/","title":{"rendered":"Assessment of Energy Expenditure"},"content":{"rendered":"<p>The mechanisms underlying the reduction in body weight produced by novel anti-obesity drugs should always be investigated by measuring the effects of the compound on both sides of the energy equation balance.<\/p>\n<h2>Energy Expenditure<\/h2>\n<p>We offer a fully comprehensive metabolic profiling service using the\u00a0TSE PhenoMaster system. This 16-cage indirect calorimetry system, equipped with motion sensors and automated food and water hoppers, can be used to determine the effects of novel test drugs on energy expenditure. \u00a0The following parameters can be measured simultaneously to elucidate the mode of action underpinning weight loss effects:<\/p>\n<ul>\n<li>Oxygen consumption (VO<sub>2<\/sub>)<\/li>\n<li>Carbon dioxide production (VCO<sub>2<\/sub>)<\/li>\n<li>Energy expenditure (derived from VO<sub>2<\/sub>and VCO<sub>2<\/sub>)<\/li>\n<li>Respiratory exchange ratio (RER; an estimate of relative substrate utilisation, ie shifts in fat and carbohydrate utilisation)<\/li>\n<li>Food and water intake<\/li>\n<li>Meal and drink patterns (ie frequency and size)<\/li>\n<li>Ambulatory and rearing activity (measured as beam breaks)).<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p>The TSE PhenoMaster can be used to study mice or rats.<\/p>\n<p>\u00a0<\/p>\n<p><strong>The beta-3 adrenoceptor agonist, CL-316,243, increases energy expenditure in the dietary-induced obese (DIO) mouse<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10254 size-full\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-beta-3-adrenoceptor-agonist-CL-316243-increases-energy-expenditure-in-the-dietary-induced-obese-DIO-mouse.png\" alt=\"Energy Expenditure\" width=\"812\" height=\"356\"><\/p>\n<p><strong>The beta-3 adrenoceptor agonist, CL-316,243, increases utilization of fat (reduces RER) in the dietary-induced obese (DIO) mouse<\/strong><\/p>\n<p><strong><img decoding=\"async\" class=\"aligncenter size-full wp-image-10255\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-beta-3-adrenoceptor-agonist-CL-316243-increases-utilization-of-fat-reduces-RER-in-the-dietary-induced-obese-DIO-mouse.png\" alt=\"\">\u00a0<\/strong><\/p>\n<p><a href=\"https:\/\/www.sygnaturediscovery.com\/contact\/\">Get in touch<\/a> for more information or <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/in-vivo-pharmacology\/metabolic-disorder-models\/\">browse our models<\/a> of metabolic disorders.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":3106,"template":"","category":[1],"resource_tag":[],"class_list":["post-3105","technical-note","type-technical-note","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - 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