{"id":3087,"date":"2021-02-16T10:54:13","date_gmt":"2021-02-16T10:54:13","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/"},"modified":"2025-11-26T14:18:01","modified_gmt":"2025-11-26T14:18:01","slug":"glucocorticoid-induced-model-of-insulin-resistance","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/","title":{"rendered":"Glucocorticoid-induced model of insulin resistance"},"content":{"rendered":"<p>We have developed a rapid model of insulin resistance induced by sub-chronic administration of the glucocorticoid, cortisone, resulting in significantly increased plasma glucose and insulin\u00a0levels\u00a0within 7 days in rats. This model can be used to evaluate the antidiabetic potential of novel drugs such as selective glucocorticoid receptor antagonists, or inhibitors of 11\u03b2 hydroxysteroid dehydrogenase (11\u03b2HSD). These enzymes catalyse the conversion of cortisone to cortisol (and\u00a0<em>vice versa<\/em>), and therefore regulate the access of glucocorticoids to steroid receptors. Below is an example demonstrating inhibition of the phenotype by mifepristone and the glucocorticoid receptor antagonist CORT125134.<\/p>\n<h3><strong><em>The glucocorticoid receptor antagonists CORT125134 and mifepristone improve cortisone-induced insulin resistance and hyperglycaemia in male Sprague Dawley rats<\/em><\/strong><\/h3>\n<p>&nbsp;<\/p>\n<h6><img decoding=\"async\" class=\"aligncenter size-full wp-image-10233\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-glucocorticoid-receptor-antagonists-CORT125134-and-mifepristone-improve-cortisone-induced-insulin-resistance-and-hyperglycaemia-in-male-Sprague-Dawley-rats.png\" alt=\"\" \/><\/h6>\n","protected":false},"excerpt":{"rendered":"<p>Explore our rapid model of glucocorticoid-induced insulin resistance, ideal for testing antidiabetic potential of new drugs. Witness the inhibitory effects of mifepristone and CORT125134 on insulin resistance and hyperglycaemia in rats.<\/p>\n","protected":false},"featured_media":3088,"template":"","category":[1],"resource_tag":[],"class_list":["post-3087","technical-note","type-technical-note","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Glucocorticoid-induced model of insulin resistance - Sygnature<\/title>\n<meta name=\"description\" content=\"Assess insulin resistance using our cortisone-induced model. See mifepristone &amp; CORT125134 effects on hyperglycaemia in rats.\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Glucocorticoid-induced model of insulin resistance - Sygnature\" \/>\n<meta property=\"og:description\" content=\"Assess insulin resistance using our cortisone-induced model. See mifepristone &amp; CORT125134 effects on hyperglycaemia in rats.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-26T14:18:01+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-glucocorticoid-receptor-antagonists-CORT125134-and-mifepristone-improve-cortisone-induced-insulin-resistance-and-hyperglycaemia-in-male-Sprague-Dawley-rats.png\" \/>\n\t<meta property=\"og:image:width\" content=\"781\" \/>\n\t<meta property=\"og:image:height\" content=\"447\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/glucocorticoid-induced-model-of-insulin-resistance\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/glucocorticoid-induced-model-of-insulin-resistance\\\/\",\"name\":\"Glucocorticoid-induced model of insulin resistance - Sygnature\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/glucocorticoid-induced-model-of-insulin-resistance\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/glucocorticoid-induced-model-of-insulin-resistance\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/The-glucocorticoid-receptor-antagonists-CORT125134-and-mifepristone-improve-cortisone-induced-insulin-resistance-and-hyperglycaemia-in-male-Sprague-Dawley-rats.png\",\"datePublished\":\"2021-02-16T10:54:13+00:00\",\"dateModified\":\"2025-11-26T14:18:01+00:00\",\"description\":\"Assess insulin resistance using our cortisone-induced model. See mifepristone & CORT125134 effects on hyperglycaemia in rats.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/glucocorticoid-induced-model-of-insulin-resistance\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/glucocorticoid-induced-model-of-insulin-resistance\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/glucocorticoid-induced-model-of-insulin-resistance\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/The-glucocorticoid-receptor-antagonists-CORT125134-and-mifepristone-improve-cortisone-induced-insulin-resistance-and-hyperglycaemia-in-male-Sprague-Dawley-rats.png\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/The-glucocorticoid-receptor-antagonists-CORT125134-and-mifepristone-improve-cortisone-induced-insulin-resistance-and-hyperglycaemia-in-male-Sprague-Dawley-rats.png\",\"width\":781,\"height\":447},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/technical-note\\\/glucocorticoid-induced-model-of-insulin-resistance\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/page-daccueil\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Glucocorticoid-induced model of insulin resistance\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"name\":\"Sygnature Discovery\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\"},\"alternateName\":\"Sygnature\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\",\"name\":\"Sygnature Discovery\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Sygnature Discovery\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Glucocorticoid-induced model of insulin resistance - Sygnature","description":"Assess insulin resistance using our cortisone-induced model. See mifepristone & CORT125134 effects on hyperglycaemia in rats.","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_CA","og_type":"article","og_title":"Glucocorticoid-induced model of insulin resistance - Sygnature","og_description":"Assess insulin resistance using our cortisone-induced model. See mifepristone & CORT125134 effects on hyperglycaemia in rats.","og_url":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/","og_site_name":"Sygnature","article_modified_time":"2025-11-26T14:18:01+00:00","og_image":[{"width":781,"height":447,"url":"http:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-glucocorticoid-receptor-antagonists-CORT125134-and-mifepristone-improve-cortisone-induced-insulin-resistance-and-hyperglycaemia-in-male-Sprague-Dawley-rats.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimation du temps de lecture":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/","url":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/","name":"Glucocorticoid-induced model of insulin resistance - Sygnature","isPartOf":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/#primaryimage"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-glucocorticoid-receptor-antagonists-CORT125134-and-mifepristone-improve-cortisone-induced-insulin-resistance-and-hyperglycaemia-in-male-Sprague-Dawley-rats.png","datePublished":"2021-02-16T10:54:13+00:00","dateModified":"2025-11-26T14:18:01+00:00","description":"Assess insulin resistance using our cortisone-induced model. See mifepristone & CORT125134 effects on hyperglycaemia in rats.","breadcrumb":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/#primaryimage","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-glucocorticoid-receptor-antagonists-CORT125134-and-mifepristone-improve-cortisone-induced-insulin-resistance-and-hyperglycaemia-in-male-Sprague-Dawley-rats.png","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/The-glucocorticoid-receptor-antagonists-CORT125134-and-mifepristone-improve-cortisone-induced-insulin-resistance-and-hyperglycaemia-in-male-Sprague-Dawley-rats.png","width":781,"height":447},{"@type":"BreadcrumbList","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/glucocorticoid-induced-model-of-insulin-resistance\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sygnaturediscovery.com\/fr\/page-daccueil\/"},{"@type":"ListItem","position":2,"name":"Glucocorticoid-induced model of insulin resistance"}]},{"@type":"WebSite","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","name":"Sygnature Discovery","description":"","publisher":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization"},"alternateName":"Sygnature","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sygnaturediscovery.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"},{"@type":"Organization","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization","name":"Sygnature Discovery","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","width":1,"height":1,"caption":"Sygnature Discovery"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/technical-note\/3087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/technical-note"}],"about":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/types\/technical-note"}],"version-history":[{"count":0,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/technical-note\/3087\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media\/3088"}],"wp:attachment":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media?parent=3087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/category?post=3087"},{"taxonomy":"resource_tag","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/resource_tag?post=3087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}