{"id":3077,"date":"2021-02-11T14:14:30","date_gmt":"2021-02-11T14:14:30","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/blood-plasma-partitioning\/"},"modified":"2021-02-11T14:14:30","modified_gmt":"2021-02-11T14:14:30","slug":"blood-plasma-partitioning","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/blood-plasma-partitioning\/","title":{"rendered":"Blood Plasma Partitioning"},"content":{"rendered":"<p>Certain drugs are highly bound to red blood cells (RBC) whilst others are highly bound to plasma proteins. As pharmacokinetics are mostly measured from plasma samples, binding to RBC can lead to dramatically miscalculated blood-derived pharmacokinetic parameters, e.g. clearance, AUC,\u00a0C<sub>max<\/sub>\u00a0and\u00a0V<sub>ss<\/sub>.<\/p>\n<p>Like plasma protein binding, binding to red blood cells (RBC) can significantly reduce a drug\u2019s free plasma concentration, i.e. the fraction of drug that is available for its pharmacological action and its elimination. A compound\u2019s pharmacodynamic and pharmacokinetic profile can hence be severely affected by its blood partitioning. Likewise, accumulation in RBC can lead to toxicity in these cells. It is, therefore, important to determine blood partitioning early during the drug discovery process.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Learn about the impact of drug binding to red blood cells (RBC) and plasma proteins on pharmacokinetics. Discover how RBC binding can affect drug concentration, pharmacological action, and potential toxicity. Understand the importance of early assessment during drug discovery.<\/p>\n","protected":false},"featured_media":0,"template":"","category":[1],"resource_tag":[],"class_list":["post-3077","technical-note","type-technical-note","status-publish","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Blood Plasma Partitioning at Sygnature Discovery<\/title>\n<meta name=\"description\" content=\"Learn about the impact of drug binding to red blood cells (RBC) and plasma proteins on pharmacokinetics. 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