{"id":3028,"date":"2018-03-07T12:51:57","date_gmt":"2018-03-07T12:51:57","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/plasma-stability\/"},"modified":"2018-03-07T12:51:57","modified_gmt":"2018-03-07T12:51:57","slug":"plasma-stability","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/plasma-stability\/","title":{"rendered":"Plasma and Blood Stability"},"content":{"rendered":"

The measurement of the stability of a new chemical entity in a matrix such as plasma<\/a> helps in identifying and understanding the lability of known structural moieties (e.g. amides, sulphonamide, esters, lactones and lactams to name a few) in molecules in the prioritisation of these for\u00a0in vivo<\/em>\u00a0PK studies. High instability can result in aberrant PK results due to high clearance and short half-lives. Species differences in plasma stability for molecules is not uncommon and should be determined.<\/p>\n

Sygnature\u2019s plasma stability assay measures the stability of molecules in mouse, rat and human plasma (please enquire about other species). The molecule to be tested and controls (positive and negative) are incubated with plasma for a defined period and the percent remaining and half-life determined.<\/p>\n

Propantheline (human), Enalapril (mouse and rat), Vinpocetin (rat) and\/or Benfluorex (human and rat) are included as positive control compounds. Pepstatin or Leupeptin are included as negative controls.<\/p>\n

For more information on microsomal metabolic stability and its impact, you can visit Sygnature Discovery’s technical note: Microsomal Metabolic Stability<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Improve in vivo PK studies by evaluating chemical stability in plasma. Our assay measures molecule stability in mouse, rat & human plasma, aiding compound prioritisation. Explore species differences. Proven positive & negative control compounds.<\/p>\n","protected":false},"featured_media":0,"template":"","category":[1],"resource_tag":[],"class_list":["post-3028","technical-note","type-technical-note","status-publish","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nPlasma & Blood Stability - Technical Notes - Sygnature Discovery<\/title>\n<meta name=\"description\" content=\"Optimise PK studies with Sygnature's plasma stability assay. 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