{"id":3017,"date":"2018-03-07T11:36:02","date_gmt":"2018-03-07T11:36:02","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/technical-note\/chemical-stability\/"},"modified":"2018-03-07T11:36:02","modified_gmt":"2018-03-07T11:36:02","slug":"chemical-stability","status":"publish","type":"technical-note","link":"https:\/\/www.sygnaturediscovery.com\/fr\/technical-note\/chemical-stability\/","title":{"rendered":"Chemical Stability"},"content":{"rendered":"

The measurement of the stability of a drug in conditions that mimic the gastrointestinal tract, physiological conditions and\/or\u00a0in vitro<\/em>\u00a0biological conditions helps in identifying and understanding the lability of molecules due to non-enzymatic processes.<\/p>\n

High chemical instability could result in aberrant\u00a0in vitro<\/em>\u00a0biological data or issues with pharmacokinetics profiles following oral dosing.<\/p>\n

Sygnature\u2019s chemical<\/a> stability assay measures the stability of a test compound in a desired matrix (e.g. buffer at different pH\u2019s or in a simulated gastric fluid environment (FaSSIF, FeSSIF, FaSSGF)). The molecule to be tested and controls (positive) are incubated in the matrix for a defined period and the percent remaining and half-life determined.<\/p>\n

Diclofenac or omeprazole are included as positive control compounds.<\/p>\n","protected":false},"excerpt":{"rendered":"

Explore drug stability assessment under physiological conditions using Sygnature’s chemical stability assay. Learn about its significance in understanding molecule lability and potential impacts on biological data and pharmacokinetics.<\/p>\n","protected":false},"featured_media":0,"template":"","category":[1],"resource_tag":[],"class_list":["post-3017","technical-note","type-technical-note","status-publish","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nChemical Stability - Sygnature Discovery<\/title>\n<meta name=\"description\" content=\"Explore drug stability assessment under physiological conditions using Sygnature's chemical stability assay. 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