{"id":13995,"date":"2019-02-06T13:00:13","date_gmt":"2019-02-06T13:00:13","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/pathios-therapeutics-et-sygnature-discovery-signent-un-partenariat-strategique\/"},"modified":"2026-02-11T09:43:11","modified_gmt":"2026-02-11T09:43:11","slug":"pathios-therapeutics-et-sygnature-discovery-signent-un-partenariat-strategique","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/pathios-therapeutics-et-sygnature-discovery-signent-un-partenariat-strategique\/","title":{"rendered":"Pathios Therapeutics et Sygnature Discovery signent un partenariat strat\u00e9gique"},"content":{"rendered":"

Pathios Therapeutics et Sygnature Discovery signent un partenariat strat\u00e9gique pour d\u00e9couvrir de nouveaux modulateurs du GPR65 destin\u00e9s au traitement des maladies auto-immunes et du cancer.<\/p>\n

Pathios Therapeutics<\/a> , une soci\u00e9t\u00e9 de biotechnologie innovante ax\u00e9e sur le d\u00e9veloppement de th\u00e9rapies novatrices pour les maladies auto-immunes et l’immuno-oncologie, et Sygnature Discovery ont annonc\u00e9 un partenariat strat\u00e9gique visant \u00e0 acc\u00e9l\u00e9rer les programmes de d\u00e9couverte et de d\u00e9veloppement de m\u00e9dicaments de Pathios.<\/p>\n

Dans le cadre de cet accord, Pathios et Sygnature collaboreront \u00e0 un programme int\u00e9gr\u00e9 de d\u00e9couverte de m\u00e9dicaments ciblant un nouveau r\u00e9cepteur coupl\u00e9 aux prot\u00e9ines G (RCPG). Plus pr\u00e9cis\u00e9ment, Sygnature apportera son expertise de pointe en biosciences et en chimie m\u00e9dicinale des RCPG afin d’\u00e9tendre le programme actuel de Pathios, qui consiste \u00e0 identifier des compos\u00e9s candidats. Sygnature d\u00e9ploiera \u00e9galement des technologies de pointe en chimie computationnelle, en conception et synth\u00e8se de chimioth\u00e8ques, ainsi qu’en criblage \u00e0 moyen d\u00e9bit, afin d’\u00e9largir le champ d’action de Pathios. Aux termes de cet accord, Sygnature recevra une participation au capital, en plus des honoraires per\u00e7us. <\/p>\n

\"\"<\/p>\n

Pathios Therapeutics r\u00e9unit la science europ\u00e9enne de pointe et une \u00e9quipe de recherche et d\u00e9veloppement de m\u00e9dicaments de premier plan afin de moduler l’activit\u00e9 de GPR65, un r\u00e9cepteur coupl\u00e9 aux prot\u00e9ines G (RCPG) sensible au pH. Cette cible th\u00e9rapeutique est caract\u00e9ristique de certaines populations de lymphocytes T auxiliaires 17 (Th17) qui contribuent significativement \u00e0 la pathologie de maladies auto-immunes telles que la spondylarthrite ankylosante et le rhumatisme psoriasique. De plus, des \u00e9tudes r\u00e9centes ont d\u00e9montr\u00e9 que GPR65 induit chez les macrophages associ\u00e9s aux tumeurs (TAM) l’adoption d’un ph\u00e9notype favorisant l’\u00e9chappement immunitaire du cancer. <\/p>\n

Tom McCarthy, pr\u00e9sident ex\u00e9cutif et cofondateur de Pathios Therapeutics Limited<\/strong>\u00ab Nous avons fond\u00e9 Pathios pour exploiter les d\u00e9couvertes scientifiques r\u00e9centes d\u00e9montrant que le GPR65 se situe au carrefour des maladies auto-immunes et de l’immuno-oncologie, ce r\u00e9cepteur \u00e9tant impliqu\u00e9 dans les pathologies induites par un pH bas. Notre objectif ultime est de bloquer le processus pathologique initi\u00e9 par le GPR65 sans interf\u00e9rer avec son r\u00f4le physiologique. Outre le d\u00e9veloppement de m\u00e9dicaments puissants et s\u00e9lectifs pour moduler le GPR65, nous poursuivons nos recherches sur les processus biologiques fondamentaux li\u00e9s aux effets du GPR65 dans les cellules Th17, les TAM et d’autres types cellulaires. Notre \u00e9quipe a d\u00e9j\u00e0 collabor\u00e9 \u00e9troitement avec Sygnature et nous savons qu’ils poss\u00e8dent l’exp\u00e9rience, l’expertise et l’infrastructure de pointe n\u00e9cessaires \u00e0 la d\u00e9couverte et au d\u00e9veloppement de m\u00e9dicaments pour faire progresser notre programme. Je suis ravi que, dans cette rare opportunit\u00e9, Sygnature ait \u00e9galement choisi d’investir dans Pathios et d’amplifier nos efforts de recherche de m\u00e9dicaments ciblant le GPR65, tandis que nous explorons des opportunit\u00e9s de financement de s\u00e9rie A. \u00bb<\/p>\n

Simon Hirst, PDG de Sygnature<\/strong> , a ajout\u00e9 :<\/strong> \u00ab Nous sommes ravis de saisir cette opportunit\u00e9 exceptionnelle de nous associer \u00e0 Pathios et d’investir dans leurs projets de d\u00e9couverte de m\u00e9dicaments. Nos analyses pr\u00e9alables nous ont permis de constater avec enthousiasme le potentiel de la modulation de GPR65 pour d\u00e9velopper de nouveaux traitements contre les maladies auto-immunes et constituer un m\u00e9canisme d’action essentiel pour les immuno-oncologies de nouvelle g\u00e9n\u00e9ration ciblant le microenvironnement tumoral. Nous sommes impatients de collaborer \u00e0 nouveau avec Tom et l’ensemble de l’\u00e9quipe talentueuse de Pathios et de contribuer \u00e0 l’impact positif potentiel de leurs th\u00e9rapies sur la vie des patients. \u00bb<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":13996,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"category":[1375,811,817,821,900,823,1319,796],"tags":[825,1376],"class_list":["post-13995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-conception-de-bibliotheque","category-conception-de-medicaments-assistee-par-ordinateur","category-domaines-therapeutiques","category-hit-pour-devenir-leader","category-ii","category-oncologie","category-rcpg","category-synthetic-chemistry","tag-decouverte-de-medicaments","tag-therapeutiques-pathios"],"acf":[],"yoast_head":"\nPathios Therapeutics et Sygnature Discovery signent un partenariat strat\u00e9gique - 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