{"id":13969,"date":"2020-06-11T12:00:54","date_gmt":"2020-06-11T12:00:54","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/sygnature-apporte-son-soutien-au-new-york-medical-college-dans-la-lutte-contre-la-covid-19\/"},"modified":"2026-02-11T09:47:22","modified_gmt":"2026-02-11T09:47:22","slug":"sygnature-apporte-son-soutien-au-new-york-medical-college-dans-la-lutte-contre-la-covid-19","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-apporte-son-soutien-au-new-york-medical-college-dans-la-lutte-contre-la-covid-19\/","title":{"rendered":"Sygnature apporte son soutien au New York Medical College dans la lutte contre la Covid-19"},"content":{"rendered":"

Nous sommes tr\u00e8s fiers de soutenir le professeur Sachin Gupte, pharmacologue au New York Medical College<\/a> (Valhalla, NY, \u00c9tats-Unis), dans ses efforts pour trouver un traitement m\u00e9dicamenteux contre les l\u00e9sions pulmonaires<\/a> pouvant r\u00e9sulter d’une infection au Covid-19<\/a> . La soci\u00e9t\u00e9 Sygnature a synth\u00e9tis\u00e9 deux compos\u00e9s importants que le professeur Gupte testera dans un mod\u00e8le de l\u00e9sion pulmonaire induite par le coronavirus. Ce travail a \u00e9t\u00e9 r\u00e9alis\u00e9 \u00e0 titre b\u00e9n\u00e9vole<\/em> .<\/p>\n

\"\"

Le professeur Sachin Gupte \u00e0 New York<\/p><\/div>\n

Les l\u00e9sions pulmonaires sont un sympt\u00f4me fr\u00e9quent chez les patients atteints de formes graves de Covid-19, notamment ceux plac\u00e9s sous ventilation m\u00e9canique. Le professeur Gupte travaille depuis un certain temps sur la G6PD, une cible th\u00e9rapeutique potentielle, initialement dans le cadre de l’hypertension art\u00e9rielle pulmonaire. Il pense que des m\u00e9dicaments agissant sur cette cible pourraient \u00e9galement \u00eatre b\u00e9n\u00e9fiques pour att\u00e9nuer les l\u00e9sions pulmonaires li\u00e9es \u00e0 la Covid-19, ce qui l’a conduit \u00e0 mener des exp\u00e9riences pour tester son hypoth\u00e8se. <\/p>\n

Cependant, il ne disposait plus de stocks de mol\u00e9cules candidates. Il a donc contact\u00e9 le Dr Allan Jordan, directeur de la d\u00e9couverte de m\u00e9dicaments en oncologie chez Sygnature, avec qui il avait collabor\u00e9 sur un pr\u00e9c\u00e9dent projet de recherche, afin de savoir si nous pouvions l’aider \u00e0 se procurer des mol\u00e9cules pour ses criblages. \u00ab Nous \u00e9tions ravis de pouvoir aider un vieil ami et collaborateur \u00bb, explique Allan. \u00ab En ces temps exceptionnels, il est important d’agir vite, et nos chimistes m\u00e9dicinaux exp\u00e9riment\u00e9s \u00e9taient parfaitement qualifi\u00e9s pour apporter leur aide. \u00bb <\/p>\n

L’\u00e9quipe Sygnature a pu se mobiliser imm\u00e9diatement, nos laboratoires \u00e9tant rest\u00e9s pleinement op\u00e9rationnels pendant toute la dur\u00e9e du confinement au Royaume-Uni. Nos scientifiques travaillent dans le strict respect des r\u00e8gles de distanciation sociale et nous avons mis en place plusieurs mesures suppl\u00e9mentaires pour garantir la sant\u00e9 et le bien-\u00eatre de nos collaborateurs. <\/p>\n

\"\"

Dr Emma Blackham dans le laboratoire de Sygnature<\/p><\/div>\n

La chercheuse principale, Emma Blackham, s’est attel\u00e9e \u00e0 la synth\u00e8se de mol\u00e9cules d\u00e9riv\u00e9es de l’androst\u00e9rone, un st\u00e9ro\u00efde. \u00ab D\u00e8s r\u00e9ception des mati\u00e8res premi\u00e8res, la synth\u00e8se s’est av\u00e9r\u00e9e relativement simple et j’ai pu produire les mol\u00e9cules rapidement \u00bb, explique-t-elle. \u00ab Je suis tr\u00e8s fi\u00e8re d’avoir pu mettre mes comp\u00e9tences en chimie \u00e0 profit. \u00bb <\/p>\n

Les mol\u00e9cules sont actuellement en route vers le laboratoire du professeur Gupte \u00e0 New York. D\u00e8s leur arriv\u00e9e, il pourra commencer les exp\u00e9riences afin d’\u00e9valuer leur potentiel dans le traitement des probl\u00e8mes pulmonaires li\u00e9s \u00e0 la Covid-19. <\/p>\n

\u00ab Les l\u00e9sions pulmonaires constituent un effet secondaire grave de la Covid-19 \u00bb, explique le professeur Gupte. \u00ab Il est encore trop t\u00f4t pour tirer des conclusions d\u00e9finitives, mais j’esp\u00e8re que des m\u00e9dicaments agissant sur la G6PD pourraient s’av\u00e9rer b\u00e9n\u00e9fiques pour ces patients. Je suis extr\u00eamement reconnaissant \u00e0 Sygnature Discovery pour son aide pr\u00e9cieuse dans la fourniture des mol\u00e9cules, sans lesquelles nous n’aurions pas pu tester cette hypoth\u00e8se dans mon laboratoire. \u00bb <\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":13970,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"category":[29],"tags":[1323,1324],"class_list":["post-13969","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-categorise","tag-covid-19-feminine","tag-faculte-de-medecine-de-new-york"],"acf":[],"yoast_head":"\nSygnature apporte son soutien au New York Medical College dans la lutte contre la Covid-19 - Sygnature<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-apporte-son-soutien-au-new-york-medical-college-dans-la-lutte-contre-la-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sygnature apporte son soutien au New York Medical College dans la lutte contre la Covid-19 - 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