{"id":13968,"date":"2019-08-01T08:45:43","date_gmt":"2019-08-01T08:45:43","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/compose-anticancereux-revolutionnaire-derive-de-la-grande-camomille\/"},"modified":"2026-02-11T09:43:13","modified_gmt":"2026-02-11T09:43:13","slug":"compose-anticancereux-revolutionnaire-derive-de-la-grande-camomille","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/compose-anticancereux-revolutionnaire-derive-de-la-grande-camomille\/","title":{"rendered":"Compos\u00e9 anticanc\u00e9reux r\u00e9volutionnaire d\u00e9riv\u00e9 de la grande camomille."},"content":{"rendered":"<p>En collaboration avec Sygnature Discovery, des chercheurs de l&rsquo; <a href=\"https:\/\/www.birmingham.ac.uk\/index.aspx\">Universit\u00e9 de Birmingham<\/a> ont d\u00e9montr\u00e9 qu&rsquo;il est possible de produire un compos\u00e9 aux propri\u00e9t\u00e9s anticanc\u00e9reuses directement \u00e0 partir de la grande camomille, une plante ornementale commune.<\/p>\n<p>Le compos\u00e9 \u00e9tudi\u00e9 par l&rsquo;\u00e9quipe s&rsquo;appelle le parth\u00e9nolide et a \u00e9t\u00e9 identifi\u00e9 par les scientifiques il y a plusieurs ann\u00e9es comme poss\u00e9dant des propri\u00e9t\u00e9s anticanc\u00e9reuses. Bien que disponible dans le commerce, il est extr\u00eamement co\u00fbteux, ses propri\u00e9t\u00e9s pharmacologiques sont m\u00e9diocres et son d\u00e9veloppement n&rsquo;a pas d\u00e9pass\u00e9 le stade de la recherche fondamentale. <\/p>\n<p>L&rsquo;\u00e9tude, publi\u00e9e aujourd&rsquo;hui dans <em>MedChemComm,<\/em> est le fruit d&rsquo;un programme multidisciplinaire r\u00e9unissant des chercheurs de Sygnature Discovery, de l&rsquo;Institut de canc\u00e9rologie et d&rsquo;\u00e9tudes g\u00e9nomiques de l&rsquo;Universit\u00e9 de Birmingham et de l&rsquo;\u00c9cole de chimie. Le jardin botanique Winterbourne de l&rsquo;Universit\u00e9 de Birmingham a supervis\u00e9 la culture des plantes en quantit\u00e9 suffisante pour permettre le criblage de m\u00e9dicaments. <\/p>\n<p>Elle a \u00e9t\u00e9 initi\u00e9e par le Dr Angelo Agathanggelou, de l&rsquo;Institut d&rsquo;\u00e9tudes sur le cancer et la g\u00e9nomique, qui \u00e9tudie de nouvelles fa\u00e7ons de traiter la leuc\u00e9mie lympho\u00efde chronique (LLC), un type de cancer qui touche g\u00e9n\u00e9ralement les personnes \u00e2g\u00e9es.<\/p>\n<p>Le Dr Agathanggelou explique&nbsp;: \u00ab&nbsp;Il existe plusieurs traitements efficaces contre la LLC, mais la maladie devient r\u00e9sistante chez certains patients au fil du temps. Nous souhaitions en savoir plus sur le potentiel du parth\u00e9nolide. Gr\u00e2ce \u00e0 l\u2019expertise de nos coll\u00e8gues de l\u2019\u00c9cole de chimie, nous avons pu d\u00e9montrer que ce compos\u00e9 est tr\u00e8s prometteur et pourrait offrir des options th\u00e9rapeutiques alternatives aux patients atteints de LLC.&nbsp;\u00bb<\/p>\n<p>Le professeur John Fossey, de l&rsquo;\u00c9cole de chimie de l&rsquo;universit\u00e9, d\u00e9clare&nbsp;: \u00ab&nbsp;Ces recherches sont importantes non seulement parce que nous avons mis au point une m\u00e9thode de production de parth\u00e9nolide qui pourrait la rendre beaucoup plus accessible aux chercheurs, mais aussi parce que nous avons r\u00e9ussi \u00e0 am\u00e9liorer ses propri\u00e9t\u00e9s pharmacologiques pour d\u00e9truire les cellules canc\u00e9reuses. C&rsquo;est une d\u00e9monstration claire du potentiel du parth\u00e9nolide, qui pourrait passer de la recherche fondamentale \u00e0 la pratique clinique.&nbsp;\u00bb <\/p>\n<p>Consultez l&rsquo;\u00e9tude ici&nbsp;:<\/p>\n<p><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/md\/c9md00297a\">Li et al (2019). &lsquo;D\u00e9rivatisation du parth\u00e9nolide pour traiter la leuc\u00e9mie lympho\u00efde chronique chimior\u00e9sistante&rsquo;.  <em>MedChemComm.<\/em> <\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":13971,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"category":[817,823],"tags":[1325],"class_list":["post-13968","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-domaines-therapeutiques","category-oncologie","tag-anti-cancer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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