{"id":13965,"date":"2019-05-28T12:25:41","date_gmt":"2019-05-28T12:25:41","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/sygnature-discovery-teste-le-spr-m\/"},"modified":"2026-02-11T09:43:12","modified_gmt":"2026-02-11T09:43:12","slug":"sygnature-discovery-teste-le-spr-m","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-teste-le-spr-m\/","title":{"rendered":"Sygnature Discovery teste le SPR-M"},"content":{"rendered":"<p>Nos biologistes viennent de terminer l&rsquo;\u00e9valuation d&rsquo;un nouvel instrument prometteur \u00e0 l&rsquo;interface de la biologie cellulaire et de la biophysique&nbsp;: un syst\u00e8me de microscopie \u00e0 r\u00e9sonance plasmonique de surface (SPR-M). Chez Sygnature Discovery, nous sommes constamment \u00e0 l&rsquo;aff\u00fbt de nouvelles technologies et techniques qui nous permettront d&rsquo;accompagner plus efficacement nos clients dans leurs projets de d\u00e9couverte de m\u00e9dicaments. <\/p>\n<p>Nous utilisons la SPR pour \u00e9tudier les interactions de liaison entre des compos\u00e9s et une prot\u00e9ine cible. Gr\u00e2ce \u00e0 l&rsquo;ajout d&rsquo;un microscope, nous pouvons observer ces m\u00eames interactions dans un contexte plus physiologique que les analyses biophysiques classiques r\u00e9alis\u00e9es sur des prot\u00e9ines isol\u00e9es et purifi\u00e9es. Cette technique combine culture cellulaire, imagerie et analyses biophysiques, et permet d&rsquo;\u00e9tudier la cin\u00e9tique de ces interactions dans un syst\u00e8me cellulaire entier. L&rsquo;utilisation de cellules plut\u00f4t que de prot\u00e9ines purifi\u00e9es offre une repr\u00e9sentation bien plus fid\u00e8le des ph\u00e9nom\u00e8nes se produisant en temps r\u00e9el dans un environnement physiologique.   <\/p>\n<p>Le nouvel instrument SPR-M200, d\u00e9velopp\u00e9 par la soci\u00e9t\u00e9 am\u00e9ricaine <a href=\"http:\/\/biosensingusa.com\/\">Biosensing Instrument<\/a> (et commercialis\u00e9 par <a href=\"https:\/\/il-biosystems.com\/uk\/\"><u>I &amp; L Biosystems<\/u><\/a> ), est en tourn\u00e9e de d\u00e9monstration au Royaume-Uni, et les laboratoires de Sygnature ont \u00e9t\u00e9 sa premi\u00e8re \u00e9tape. Pendant qu\u2019il \u00e9tait avec nous, nous avons r\u00e9alis\u00e9 une \u00e9tude d\u2019\u00e9valuation sur un r\u00e9cepteur coupl\u00e9 aux prot\u00e9ines G (RCPG), le r\u00e9cepteur de la neurotensine 1 (NTS1). En utilisant une lign\u00e9e cellulaire exprimant de mani\u00e8re endog\u00e8ne NTS1, la cin\u00e9tique de liaison a \u00e9t\u00e9 d\u00e9termin\u00e9e pour un certain nombre de petites mol\u00e9cules et un anticorps. Ces ensembles de donn\u00e9es sont comparables aux exemples rapport\u00e9s dans la litt\u00e9rature o\u00f9 des constructions NTS1 stabilis\u00e9es, mutantes et autres constructions non physiologiques ont d\u00fb \u00eatre d\u00e9velopp\u00e9es.<\/p>\n<p>Bien qu&rsquo;une grande partie des cibles th\u00e9rapeutiques appartiennent \u00e0 la classe des RCPG, elles ne sont pas les seules prot\u00e9ines membranaires de surface \u00e0 b\u00e9n\u00e9ficier d&rsquo;\u00e9tudes SPR-M&nbsp;; cette technique est \u00e9galement applicable \u00e0 d&rsquo;autres cibles importantes, telles que les canaux ioniques et les prot\u00e9ines de transport. Dans chaque cas, elle permet une caract\u00e9risation biophysique compl\u00e8te, fournissant des donn\u00e9es pr\u00e9cieuses sur ces cibles dans leur environnement cellulaire. <\/p>\n<p>Jamie Ware, scientifique principal chez Sygnature Discovery, a comment\u00e9 : \u00ab La facilit\u00e9 de <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/bioscience\/assay-development\/\">d\u00e9veloppement des tests<\/a> et le court d\u00e9lai requis pour fournir un test de liaison de haute qualit\u00e9 pour cette classe difficile de cibles m\u00e9dicamenteuses peuvent avoir un impact profond sur la d\u00e9couverte de m\u00e9dicaments \u00e0 un stade pr\u00e9coce, ce qui fait de la SPR-M une technologie tr\u00e8s pr\u00e9cieuse pour nos partenaires de d\u00e9couverte de m\u00e9dicaments. \u00bb<\/p>\n<p>Scott Pollack, directeur adjoint du d\u00e9partement de biosciences, a ajout\u00e9&nbsp;: \u00ab&nbsp;Nous appr\u00e9cions la fa\u00e7on dont la SPR-M nous permet de combiner le meilleur de deux mondes&nbsp;: l\u2019analyse biophysique en temps r\u00e9el des \u00e9v\u00e9nements de liaison et leur observation dans un contexte cellulaire et physiologique. Il s\u2019agit d\u2019une technique tr\u00e8s prometteuse pour l\u2019\u00e9tude des prot\u00e9ines membranaires int\u00e9grales complexes. Notre prochaine \u00e9tape consistera \u00e0 appliquer cette technologie \u00e0 l\u2019un des projets de l\u2019un de nos clients.&nbsp;\u00bb<\/p>\n<p>Si vous avez des questions ou souhaitez discuter de nos comp\u00e9tences en <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/bioscience\/biophysical-assays\/\">biophysique<\/a> ou <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/\">en d\u00e9couverte de m\u00e9dicaments<\/a> en g\u00e9n\u00e9ral, n&rsquo;h\u00e9sitez pas \u00e0 nous contacter. Vous pouvez nous contacter via le <a href=\"https:\/\/www.sygnaturediscovery.com\/contact\/\">formulaire de contact<\/a> ou en nous envoyant un courriel \u00e0 <a href=\"mailto:info@sygnaturediscovery.com\">info@sygnaturediscovery.com<\/a> .<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":13966,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"category":[790,1262,1319],"tags":[],"class_list":["post-13965","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bioscience","category-essais-biophysiques","category-rcpg"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sygnature Discovery teste le SPR-M - Sygnature<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-teste-le-spr-m\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sygnature Discovery teste le SPR-M - 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