{"id":13953,"date":"2016-02-03T11:25:13","date_gmt":"2016-02-03T11:25:13","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/sygnature-discovery-fournit-plus-de-21-000-nouveaux-composes-a-leuropean-lead-factory-lune-des-pme-les-plus-performantes-du-consortium\/"},"modified":"2016-02-03T11:25:13","modified_gmt":"2016-02-03T11:25:13","slug":"sygnature-discovery-fournit-plus-de-21-000-nouveaux-composes-a-leuropean-lead-factory-lune-des-pme-les-plus-performantes-du-consortium","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-fournit-plus-de-21-000-nouveaux-composes-a-leuropean-lead-factory-lune-des-pme-les-plus-performantes-du-consortium\/","title":{"rendered":"Sygnature Discovery fournit plus de 21 000 nouveaux compos\u00e9s \u00e0 l’European Lead Factory, l’une des PME les plus performantes du consortium."},"content":{"rendered":"

Sygnature Discovery a annonc\u00e9 avoir livr\u00e9 plus de 21 000 nouveaux compos\u00e9s chimiques \u00e0 la Collection publique de compos\u00e9s (PCC) de l’ European<\/a> Lead Factory (ELF).<\/p>\n

Lanc\u00e9 en 2013, le projet ELF est une initiative collaborative de 196 millions d’euros financ\u00e9e par l’Initiative pour les m\u00e9dicaments innovants (IMI) et visant \u00e0 acc\u00e9l\u00e9rer les phases initiales du processus de d\u00e9couverte de m\u00e9dicaments. Des entreprises pharmaceutiques, des groupes de recherche universitaires et dix PME, dont Sygnature Discovery, ont form\u00e9 un consortium paneurop\u00e9en pour relever le d\u00e9fi de la mise \u00e0 disposition d’une base de donn\u00e9es innovante et accessible au public, le PCC (Platform Criteria Center), contenant des compos\u00e9s synth\u00e9tiquement accessibles. Dans le cadre de l’ELF, les sept entreprises pharmaceutiques participantes ont fourni plus de 300 000 compos\u00e9s chimiques issus de leurs collections, tandis que les groupes de recherche universitaires et les cinq PME membres du consortium, dont Sygnature Discovery, fourniront 200 000 compos\u00e9s provenant de domaines inexplor\u00e9s de l’espace chimique biologiquement pertinent d’ici fin 2017. <\/p>\n

En novembre 2015, une publication scientifique parue dans \u00ab Drug Discovery Today \u00bb (Vol. 20, n\u00b0 11, p. 1310-1316) d\u00e9taillait les r\u00e9sultats d\u2019une \u00e9tude comparative r\u00e9alis\u00e9e sur les 50 000 premiers compos\u00e9s de la collection de criblage con\u00e7us et synth\u00e9tis\u00e9s au sein du consortium ELF, et livr\u00e9s avant mars 2015. Le criblage \u00e0 haut d\u00e9bit (HTS) constitue un pilier majeur de la d\u00e9couverte de m\u00e9dicaments, et la disponibilit\u00e9 d\u2019une collection de compos\u00e9s innovante, pertinente et de haute qualit\u00e9 \u00e0 cribler d\u00e9termine souvent l\u2019issue d\u2019une campagne de recherche. \u00c9tant donn\u00e9 que l\u2019espace chimique \u00e0 explorer dans les programmes de recherche pharmaceutique est pratiquement infini et peu peupl\u00e9, des efforts et des ressources consid\u00e9rables doivent \u00eatre investis dans la g\u00e9n\u00e9ration et le maintien d\u2019une collection de compos\u00e9s comp\u00e9titive. Le projet ELF rel\u00e8ve ce d\u00e9fi en tirant parti de l’exp\u00e9rience et du savoir-faire diversifi\u00e9s des groupes universitaires et des PME engag\u00e9es dans la chimie de synth\u00e8se et\/ou m\u00e9dicinale, en concevant et en synth\u00e9tisant une collection de compos\u00e9s pr\u00e9sentant nouveaut\u00e9, diversit\u00e9, complexit\u00e9 structurelle, caract\u00e9ristiques physico-chimiques favorables et un attrait global pour les besoins du criblage \u00e0 haut d\u00e9bit. <\/p>\n

Les nouveaux compos\u00e9s de la PCC pr\u00e9sentent de bonnes propri\u00e9t\u00e9s de type Lipinski, une forte proportion de centres sp\u00b3<\/sup> (caract\u00e8re Fsp\u00b3) et 85 % d’entre eux sont chiraux, ce qui leur conf\u00e8re une structure tridimensionnelle complexe. De plus, plus de la moiti\u00e9 des structures mol\u00e9culaires de la collection sont uniques, offrant ainsi un r\u00e9el potentiel pour explorer de nouveaux domaines de la biologie, jusqu’alors inaccessibles, ou pour cibler diff\u00e9remment des voies pathologiques connues. Le caract\u00e8re novateur des \u00e9chafaudages mol\u00e9culaires des 50 000 premiers compos\u00e9s de la PCC souligne l’innovation radicale apport\u00e9e \u00e0 l’ELF en seulement deux ans par les PME de chimie, telles que Sygnature, et leurs partenaires acad\u00e9miques. <\/p>\n

Le Dr Simon Hirst, fondateur et directeur g\u00e9n\u00e9ral de Sygnature Discovery, a d\u00e9clar\u00e9 : \u00ab Sygnature est fi\u00e8re de compter parmi les PME les plus productives du secteur de la chimie, ayant contribu\u00e9 \u00e0 hauteur de plus de 21 000 nouveaux compos\u00e9s \u00e0 la collaboration ELF. Ce consortium de PME et d\u2019universitaires a fourni au total pr\u00e8s de 100 000 compos\u00e9s dot\u00e9s de structures novatrices susceptibles d\u2019acc\u00e9l\u00e9rer la d\u00e9couverte de m\u00e9dicaments en Europe et au-del\u00e0. Nous sommes impatients de poursuivre notre collaboration avec tous nos partenaires de l\u2019ELF afin de fournir les compos\u00e9s restants au PCC d\u2019ici la fin de l\u2019ann\u00e9e 2017. \u00bb<\/p>\n

\u00c0 propos de l’Initiative pour les m\u00e9dicaments innovants<\/strong><\/p>\n

L\u2019Initiative pour les m\u00e9dicaments innovants (IMI) est le plus grand partenariat public-priv\u00e9 au monde dans le domaine de la sant\u00e9. L\u2019IMI am\u00e9liore l\u2019environnement de l\u2019innovation pharmaceutique en Europe en mobilisant et en soutenant des r\u00e9seaux d\u2019experts industriels et acad\u00e9miques dans le cadre de projets de recherche collaboratifs. L\u2019Union europ\u00e9enne contribue \u00e0 hauteur d\u2019un milliard d\u2019euros au programme de recherche de l\u2019IMI, une somme compl\u00e9t\u00e9e par des contributions en nature d\u2019une valeur d\u2019au moins un milliard d\u2019euros de la part des entreprises membres de la F\u00e9d\u00e9ration europ\u00e9enne des industries et associations pharmaceutiques (EFPIA). L\u2019Initiative pour les m\u00e9dicaments innovants soutient actuellement 40 projets, dont beaucoup produisent d\u00e9j\u00e0 des r\u00e9sultats impressionnants. Tous ces projets s\u2019attaquent aux principaux obstacles au d\u00e9veloppement des m\u00e9dicaments et permettront ainsi d\u2019acc\u00e9l\u00e9rer la mise au point de traitements plus s\u00fbrs et plus efficaces pour les patients. <\/p>\n

Les recherches ayant abouti \u00e0 ces r\u00e9sultats ont b\u00e9n\u00e9fici\u00e9 du soutien de l’Initiative conjointe pour les m\u00e9dicaments innovants (IMI) dans le cadre de la convention de subvention n\u00b0 115489. Ce soutien est assur\u00e9 par une contribution financi\u00e8re du septi\u00e8me programme-cadre de l’Union europ\u00e9enne (FP7\/2007-2013) et par des contributions en nature d’entreprises membres de l’EFPIA. Plus d’informations : http:\/\/www.imi.europa.eu\/content\/european-lead-factory<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"category":[29],"tags":[802,1261,1276,1265,824,825,1269,1271,1274,1272,1263,1278,1267],"class_list":["post-13953","post","type-post","status-publish","format-standard","hentry","category-non-categorise","tag-21k","tag-chimie-medicinale","tag-collection-publique","tag-contribuer","tag-decouverte-de-la-signature","tag-decouverte-de-medicaments","tag-depistage-hts","tag-initiative-pour-les-medicaments-innovants","tag-innovation-pharmaceutique","tag-nouveaux-composes","tag-pme-en-chimie","tag-pme-performantes","tag-usine-de-plomb-europeenne"],"acf":[],"yoast_head":"\nSygnature Discovery fournit plus de 21 000 nouveaux compos\u00e9s \u00e0 l'European Lead Factory, l'une des PME les plus performantes du consortium. - 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