{"id":13938,"date":"2016-07-04T10:00:12","date_gmt":"2016-07-04T10:00:12","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/integration-du-systeme-dimagerie-confocale-a-haut-contenu-imagexpress\/"},"modified":"2026-02-05T12:27:45","modified_gmt":"2026-02-05T12:27:45","slug":"integration-du-systeme-dimagerie-confocale-a-haut-contenu-imagexpress","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/integration-du-systeme-dimagerie-confocale-a-haut-contenu-imagexpress\/","title":{"rendered":"Int\u00e9gration du syst\u00e8me d&rsquo;imagerie confocale \u00e0 haut contenu ImageXpress\u00ae"},"content":{"rendered":"<p>Sygnature Discovery Limited, fournisseur mondial de services int\u00e9gr\u00e9s de d\u00e9couverte de m\u00e9dicaments, annonce l&rsquo;int\u00e9gration du syst\u00e8me d&rsquo;imagerie confocale \u00e0 haut d\u00e9bit ImageXpress\u00ae Micro au sein de son d\u00e9partement de biosciences. Ce syst\u00e8me haute r\u00e9solution renforce l&rsquo;expertise de Sygnature en imagerie cellulaire, s&rsquo;appuyant sur l&rsquo;int\u00e9gration r\u00e9cente de la technologie <a href=\"https:\/\/www.sygnaturediscovery.com\/news-and-events\/news\/adoption-of-incucyte-zoom\/\">IncuCyte\u00ae ZOOM<\/a> pour l&rsquo;analyse de cellules vivantes en temps r\u00e9el. <\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1107 \" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/ImageXpress-150x150-1.jpg\" alt=\"Adoption du syst\u00e8me d'imagerie confocale \u00e0 haut contenu ImageXpress\u00ae\" width=\"157\" height=\"157\"><\/p>\n<p>Le Dr John Unitt, directeur des biosciences, a comment\u00e9&nbsp;:<\/p>\n<blockquote><p><em>Le syst\u00e8me d&rsquo;imagerie confocale \u00e0 haut d\u00e9bit ImageXpress\u00ae Micro permet \u00e0 nos scientifiques de capturer des images de haute qualit\u00e9 gr\u00e2ce \u00e0 une large gamme d&rsquo;objectifs et \u00e0 la possibilit\u00e9 de multiplexer jusqu&rsquo;\u00e0 5 longueurs d&rsquo;onde, y compris la lumi\u00e8re transmise. Les modes d&rsquo;imagerie grand champ et confocal offrent la sensibilit\u00e9 et la r\u00e9solution requises pour chaque analyse. Associ\u00e9 au logiciel d&rsquo;acquisition et d&rsquo;analyse d&rsquo;images MetaXpress\u00ae High-Content PowerCore, le syst\u00e8me ImageXpress\u00ae Micro Confocal constitue une solution compl\u00e8te de criblage multidimensionnel \u00e0 haut d\u00e9bit. L&rsquo;adoption du syst\u00e8me d&rsquo;imagerie confocale ImageXpress\u00ae Micro a renforc\u00e9 les capacit\u00e9s de recherche <a href=\"https:\/\/www.sygnaturediscovery.com\/\" target=\"_blank\" rel=\"noopener\">de Sygnature Discovery<\/a> dans de nombreux domaines th\u00e9rapeutiques, tels que l&rsquo;oncologie, l&rsquo;immunologie, l&rsquo;inflammation et les neurosciences, ce qui profitera aux projets de nos clients.   <\/em><\/p><\/blockquote>\n<h2>Sygnature Discovery propose des analyses utilisant le syst\u00e8me d&rsquo;imagerie confocale micro ImageXpress\u00ae&nbsp;:<\/h2>\n<ul>\n<li>\n<h3><strong>Angiogen\u00e8se &#8211;  <\/strong><\/h3>\n<ul>\n<li>Mesures de la formation de tubes vasculaires \u00e0 l&rsquo;aide de mod\u00e8les de co-culture de cellules endoth\u00e9liales\/fibroblastes<\/li>\n<li>Coloration par immunofluorescence pour marquer sp\u00e9cifiquement les noyaux, les fibroblastes, les cellules endoth\u00e9liales et les membranes basales.<\/li>\n<li>Acquisition unique en s\u00e9rie Z et fusion en une seule image \u00e0 mise au point optimale pour capturer le comportement tridimensionnel des cellules<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-1108\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HUVEC-cells.png\" alt=\"\"><\/p>\n<ul>\n<li>\n<h3><strong>\u00c9tudes neuronales &#8211;<\/strong><\/h3>\n<ul>\n<li>Mesure et quantification de la dynamique et de la structure des neurites par fluorescence ou lumi\u00e8re transmise&nbsp;: longueur, ramification et r\u00e9traction des neurites, nombre de corps cellulaires<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<h3><strong>Mod\u00e9lisation de la fibrose &#8211;<\/strong><\/h3>\n<ul>\n<li>Mesure, comptage et enregistrement des mesures de cellules dans des exp\u00e9riences de notation cellulaire \u00e0 longueurs d&rsquo;onde multiples<\/li>\n<li>Identification de sous-populations de cellules<\/li>\n<li>mesures de terrain et cellule par cellule<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-1109\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/NRK49F-cells.png\" alt=\"\"><\/p>\n<ul>\n<li>\n<h3><strong>\u00c9tudes de colocalisation de marqueurs &#8211;  <\/strong><\/h3>\n<ul>\n<li>D\u00e9tection, mesure et sommation simultan\u00e9es des surfaces de plusieurs marqueurs ou corps color\u00e9s.<\/li>\n<\/ul>\n<\/li>\n<li>\n<h3><strong>Sph\u00e9ro\u00efdes 3D &#8211;  <\/strong><\/h3>\n<ul>\n<li>Acquisition \u00e0 partir de divers formats de plaques multipuits, y compris des formats d\u00e9velopp\u00e9s pour les analyses 3D tels que les plaques \u00e0 fond rond et les plaques trans-puits.<\/li>\n<li>Analyse d&rsquo;\u00e9chantillons 3D par capture d&rsquo;une s\u00e9rie Z \u00e0 travers le sph\u00e9ro\u00efde et fusion des images pour g\u00e9n\u00e9rer une image \u00e0 mise au point optimale, ou utilisation des images de la s\u00e9rie Z pour visualiser l&rsquo;\u00e9chantillon en 3D.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<h3><strong>Internalisation des r\u00e9cepteurs &#8211;<\/strong><\/h3>\n<ul>\n<li>D\u00e9tection de la translocation des r\u00e9cepteurs intracellulaires (marquage par fluorescence ou par anticorps fluorescents) ainsi que d&rsquo;autres marqueurs endosomaux intracellulaires<\/li>\n<\/ul>\n<\/li>\n<li>\n<h3><strong>Cytotoxicit\u00e9 et apoptose &#8211;  <\/strong><\/h3>\n<ul>\n<li>Mesure quantitative de la viabilit\u00e9 cellulaire et de l&rsquo;apoptose dans des tests multiplex utilisant des marqueurs fluorescents appropri\u00e9s<\/li>\n<li>D\u00e9tection de l&rsquo;int\u00e9grit\u00e9 mitochondriale \u00e0 l&rsquo;aide de colorants du potentiel de membrane interne des mitochondries<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<h3><strong>Cycle cellulaire &#8211;  <\/strong><\/h3>\n<ul>\n<li>Mesure et quantification des stades du cycle cellulaire.<\/li>\n<li>Colorants optionnels sp\u00e9cifiques \u00e0 l&rsquo;apoptose et \u00e0 la mitose.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>\u00c0 propos de Sygnature Discovery<\/strong><\/p>\n<p>Sygnature Discovery est le plus important fournisseur ind\u00e9pendant britannique de ressources et d&rsquo;expertise int\u00e9gr\u00e9es en mati\u00e8re de d\u00e9couverte de m\u00e9dicaments. Notre mission est d&rsquo;acc\u00e9l\u00e9rer le d\u00e9veloppement clinique de nouveaux m\u00e9dicaments potentiels afin de traiter des patients atteints de maladies invalidantes et souvent mortelles. Sygnature exploite un centre de R&amp;D ultramoderne abritant des laboratoires et plus de 110 chercheurs exp\u00e9riment\u00e9s, dot\u00e9s de toutes les comp\u00e9tences professionnelles requises pour mener \u00e0 bien les projets de d\u00e9couverte de m\u00e9dicaments les plus exigeants. L&rsquo;entreprise apporte une valeur ajout\u00e9e consid\u00e9rable aux collaborations en fournissant des connaissances scientifiques de pointe et une expertise intellectuelle permettant d&rsquo;acc\u00e9l\u00e9rer les projets de d\u00e9couverte de m\u00e9dicaments de ses clients, de la validation de la cible \u00e0 l&rsquo;optimisation des compos\u00e9s candidats, en passant par l&rsquo;identification et l&rsquo;optimisation de ces compos\u00e9s. Les comp\u00e9tences de Sygnature couvrent la chimie m\u00e9dicinale, les biosciences, les sciences computationnelles\/l&rsquo;informatique, la DMPK\/les sciences physiques et la cristallographie des prot\u00e9ines ( <em>via<\/em> sa filiale Peak Proteins). L&rsquo;entreprise b\u00e9n\u00e9ficie d&rsquo;un bilan exceptionnel en mati\u00e8re de r\u00e9ussite pour ses clients. Actuellement, 7 candidats m\u00e9dicaments sont en phase clinique et 15 compos\u00e9s en d\u00e9veloppement pr\u00e9clinique, tous issus de Sygnature Discovery. Pour plus d&rsquo;informations, consultez le site&nbsp;: <a href=\"https:\/\/www.sygnaturediscovery.com\/\">onesygnaturdev.wpenginepowered.com<\/a>       <\/p>\n<p><strong>Contacts :<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"294\">Dr Simon Hirst, fondateur et directeur g\u00e9n\u00e9ral<\/p>\n<p> Sygnature Discovery Limited<\/p>\n<p> Courriel&nbsp;: <a href=\"mailto:busdev@sygnaturediscovery.com\">busdev@sygnaturediscovery.com<\/a><\/td>\n<td width=\"320\">&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><u> <\/u><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00a9 2016 Sygnature Discovery Ltd. Tous droits r\u00e9serv\u00e9s. <\/strong><\/p>\n<p>Sygnature Discovery Limited est une soci\u00e9t\u00e9 constitu\u00e9e en Angleterre et au Pays de Galles, sous le num\u00e9ro 05210563, dont le si\u00e8ge social et le principal \u00e9tablissement se trouvent \u00e0 BioCity, Pennyfoot Street, Nottingham, NG1 1GF, Royaume-Uni.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":13940,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"category":[790,843],"tags":[1231,1227,1054,1052,1229,1230,1232,1233,1228,1234],"class_list":["post-13938","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bioscience","category-tests-cellulaires","tag-analyse-de-contenu-de-haut-niveau","tag-analyses-avancees","tag-decouverte-de-la-signature-2","tag-decouverte-de-medicaments-3","tag-imagerie-cellulaire","tag-imagerie-confocale","tag-imagexpress","tag-microscopytech","tag-outils-de-bioscience","tag-recherche-et-technologie"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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