{"id":13926,"date":"2014-09-23T10:59:28","date_gmt":"2014-09-23T10:59:28","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/bergenbio-a-recu-un-prestigieux-prix-wellcome-trust-seeding-drug-discovery-award\/"},"modified":"2026-02-05T12:25:51","modified_gmt":"2026-02-05T12:25:51","slug":"bergenbio-a-recu-un-prestigieux-prix-wellcome-trust-seeding-drug-discovery-award","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/bergenbio-a-recu-un-prestigieux-prix-wellcome-trust-seeding-drug-discovery-award\/","title":{"rendered":"BerGenBio a re\u00e7u un prestigieux prix Wellcome Trust Seeding Drug Discovery Award."},"content":{"rendered":"

Seize millions de couronnes norv\u00e9giennes ont \u00e9t\u00e9 allou\u00e9es au d\u00e9veloppement d’un nouveau traitement contre le cancer.<\/strong><\/p>\n

BerGenBio AS (\u00ab BerGenBio \u00bb ou la \u00ab Soci\u00e9t\u00e9 \u00bb), une soci\u00e9t\u00e9 biopharmaceutique sp\u00e9cialis\u00e9e en oncologie, annonce aujourd\u2019hui qu\u2019elle a obtenu un financement de 1,6 million de livres sterling (16 millions de couronnes norv\u00e9giennes).<\/p>\n

BerGenBio a re\u00e7u une subvention du Wellcome Trust (Royaume-Uni) pour d\u00e9velopper de nouveaux inhibiteurs de petites mol\u00e9cules ciblant BGB002, sa cible canc\u00e9reuse exclusive et novatrice. Les subventions du Wellcome Trust pour la d\u00e9couverte de m\u00e9dicaments visent \u00e0 identifier et financer des concepts th\u00e9rapeutiques particuli\u00e8rement prometteurs et innovants, de leur mise en \u0153uvre clinique jusqu’\u00e0 leur candidature. Les candidatures sont tr\u00e8s comp\u00e9titives. BGB002 est une nouvelle cible canc\u00e9reuse identifi\u00e9e par BerGenBio, qui contr\u00f4le les caract\u00e9ristiques malignes des cellules tumorales. Ce g\u00e8ne est surexprim\u00e9 dans plusieurs types de cancers, notamment les cancers difficiles \u00e0 traiter comme le cancer du sein triple n\u00e9gatif. Gr\u00e2ce \u00e0 sa technologie CellSelect\u2122, BerGenBio a d\u00e9montr\u00e9 que BGB002 active fortement la transition \u00e9pith\u00e9lio-m\u00e9senchymateuse (TEM) des cellules tumorales, un pr\u00e9curseur de la diss\u00e9mination m\u00e9tastatique. Des \u00e9tudes de validation de la cible ont ensuite d\u00e9montr\u00e9 le r\u00f4le unique et crucial de BGB002 dans la m\u00e9diation de la TEM, facilitant l’\u00e9chappement des cellules transform\u00e9es et engendrant une r\u00e9sistance aux traitements anticanc\u00e9reux standards. <\/p>\n

Cette attribution, sous forme de pr\u00eat convertible, financera la prochaine phase du projet de d\u00e9veloppement BGB002 de la soci\u00e9t\u00e9 au cours des 12 prochains mois.<\/p>\n

Richard Godfrey, directeur g\u00e9n\u00e9ral de BerGenBio, a comment\u00e9 :
\n \u00ab L\u2019obtention de cette bourse Wellcome Trust Seeding Drug Discovery Award est une formidable r\u00e9ussite et une reconnaissance incontestable de l\u2019expertise de BerGenBio dans l\u2019identification des principaux facteurs mol\u00e9culaires des cancers agressifs r\u00e9sistants aux m\u00e9dicaments, ainsi que de notre capacit\u00e9 \u00e0 transformer ces d\u00e9couvertes en candidats m\u00e9dicaments viables. Je suis particuli\u00e8rement fier de la collaboration fructueuse entre nos \u00e9quipes et celle de Sygnature. Leur collaboration est remarquable et leurs comp\u00e9tences compl\u00e9mentaires. Les scientifiques de BerGenBio et de Sygnature ont travaill\u00e9 de concert sur leurs sites respectifs pour \u00e9laborer un dossier de candidature tr\u00e8s convaincant et ont pr\u00e9sent\u00e9 avec succ\u00e8s le projet conjointement lors de l\u2019\u00e9valuation finale. \u00bb <\/p>\n

\u00ab La fondation Wellcome Trust re\u00e7oit des centaines de demandes de financement de ce type et n’accorde que quelques subventions chaque ann\u00e9e \u00e0 des projets faisant preuve d’une science et d’une innovation exceptionnelles et qui s’efforcent de r\u00e9pondre \u00e0 un besoin m\u00e9dical important non satisfait. \u00bb<\/p>\n

\u00ab Ce financement contribuera \u00e0 nos efforts de recherche et d\u00e9veloppement visant \u00e0 d\u00e9couvrir de nouvelles th\u00e9rapies \u00e0 base de petites mol\u00e9cules pour traiter les cancers agressifs et r\u00e9sistants. \u00bb<\/p>\n

-Fin-<\/p>\n

Pour plus d’informations, veuillez contacter :
\n BerGenBio AS +47 917 86 304
\n Richard Godfrey, PDG
\n Demandes des m\u00e9dias
\n FTI Consulting +44 (0) 20 3727 1000
\n Simon Conway \/ Rob Winder \/ Natalie Garland-Collins<\/p>\n

\u00c0 propos de BerGenBio AS
\n BerGenBio AS est une soci\u00e9t\u00e9 biopharmaceutique en phase clinique. Elle s’engage \u00e0 d\u00e9velopper des th\u00e9rapies innovantes inhibant la transition \u00e9pith\u00e9lio-m\u00e9senchymateuse (EMT), pr\u00e9venant la formation de cellules souches canc\u00e9reuses et perturbant les m\u00e9canismes cellulaires responsables de la r\u00e9sistance acquise aux m\u00e9dicaments anticanc\u00e9reux. La soci\u00e9t\u00e9 repose sur la plateforme technologique propri\u00e9taire CellSelect\u2122, qui exploite les donn\u00e9es issues d’\u00e9tudes de criblage par ARN interf\u00e9rence (ARNi) pour identifier et valider de nouvelles cibles th\u00e9rapeutiques et de nouveaux biomarqueurs. Le BGB324 est le premier compos\u00e9 du portefeuille de BerGenBio \u00e0 entrer en essais cliniques dans la leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb (LMA) et le cancer du poumon non \u00e0 petites cellules (CPNPC). D’autres compos\u00e9s et cibles th\u00e9rapeutiques sont \u00e0 diff\u00e9rents stades de d\u00e9veloppement pr\u00e9clinique. www.bergenbio.com <\/p>\n

\u00c0 propos du Wellcome Trust
\n Le Wellcome Trust est la deuxi\u00e8me fondation caritative mondiale en termes de d\u00e9penses. Elle se consacre \u00e0 l’am\u00e9lioration significative de la sant\u00e9 humaine et animale. Elle soutient des chercheurs de renom dans les domaines de la recherche biom\u00e9dicale et des humanit\u00e9s m\u00e9dicales, notamment par la sensibilisation du public, l’\u00e9ducation et l’application de la recherche \u00e0 l’am\u00e9lioration de la sant\u00e9. Elle est ind\u00e9pendante de tout int\u00e9r\u00eat politique et commercial.
\n www.wellcome.ac.uk <\/p>\n

Pour plus d’informations sur le prix Seeding Drug Discovery Award, veuillez consulter le site web du Wellcome Trust :<\/p>\n

http:\/\/j.mp\/SeedingDrugDiscovery<\/p>\n

\u00c0 propos de Sygnature Discovery Ltd.
\n Sygnature Discovery est le plus important fournisseur ind\u00e9pendant britannique de services int\u00e9gr\u00e9s de d\u00e9couverte de m\u00e9dicaments. Ses comp\u00e9tences cl\u00e9s incluent la chimie m\u00e9dicinale, les biosciences in vitro<\/span> , la chimie computationnelle et l’informatique. Nous proposons \u00e9galement des services d’ADME, de toxicologie in vitro<\/span> , de pharmacologie de s\u00e9curit\u00e9 pr\u00e9coce, de mod\u00e8les d’efficacit\u00e9 in vivo<\/span> , d’expertise en canaux ioniques, de production de prot\u00e9ines et de cristallographie aux rayons X, adapt\u00e9s aux besoins sp\u00e9cifiques de nos clients et gr\u00e2ce \u00e0 des partenariats strat\u00e9giques de longue date. onesygnaturdev.wpenginepowered.com<\/p>\n

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