{"id":13911,"date":"2016-03-16T11:18:04","date_gmt":"2016-03-16T11:18:04","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/ladoption-dincucyte-zoom-renforce-les-capacites-de-syngnature-discovery\/"},"modified":"2026-02-05T12:24:49","modified_gmt":"2026-02-05T12:24:49","slug":"ladoption-dincucyte-zoom-renforce-les-capacites-de-syngnature-discovery","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/ladoption-dincucyte-zoom-renforce-les-capacites-de-syngnature-discovery\/","title":{"rendered":"L&rsquo;adoption d&rsquo;IncuCyte\u00ae ZOOM renforce les capacit\u00e9s de Syngnature Discovery."},"content":{"rendered":"<div class=\"wpb_text_column\">\n<p><img decoding=\"async\" class=\"size-full wp-image-1136 aligncenter\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/IncuCyte-Zoom-150x150-1.png\" alt=\"\"><\/p>\n<p>Sygnature Discovery Limited, une soci\u00e9t\u00e9 qui entreprend des projets int\u00e9gr\u00e9s de d\u00e9couverte de m\u00e9dicaments pour des entreprises pharmaceutiques et biotechnologiques du monde entier, de la validation de la cible au candidat-m\u00e9dicament, a annonc\u00e9 aujourd&rsquo;hui l&rsquo;ajout de la technologie d&rsquo;analyse quantitative en temps r\u00e9el de cellules vivantes IncuCyte\u00ae ZOOM \u00e0 son d\u00e9partement des biosciences.<\/p>\n<p>En juillet 2015, Sygnature et Essen BioScience Ltd., leader mondial des tests et instruments cellulaires <em>in vitro<\/em> , ont annonc\u00e9 la mise en place d&rsquo;une alliance strat\u00e9gique visant \u00e0 int\u00e9grer les technologies uniques d&rsquo;Essen en mati\u00e8re de tests ph\u00e9notypiques, d&rsquo;imagerie cellulaire en temps r\u00e9el et de canaux ioniques aux projets de d\u00e9couverte de m\u00e9dicaments int\u00e9gr\u00e9s de Sygnature. Cette alliance s&rsquo;est av\u00e9r\u00e9e tr\u00e8s fructueuse et a notamment permis \u00e0 Sygnature d&rsquo;int\u00e9grer le syst\u00e8me IncuCyte\u00ae ZOOM \u00e0 ses capacit\u00e9s internes. <\/p>\n<p>IncuCyte\u00ae ZOOM offre une imagerie cellulaire continue sur plaque, au sein d&rsquo;un environnement de culture tissulaire contr\u00f4l\u00e9, permettant une analyse quantitative non invasive et en temps r\u00e9el de cellules vivantes. L&rsquo;\u00e9tude des syst\u00e8mes cellulaires par imagerie de cellules vivantes pr\u00e9sente de nombreux avantages par rapport aux analyses fonctionnelles cellulaires classiques \u00e0 point final unique&nbsp;: analyse sans marquage, absence de perturbation cellulaire pendant l&rsquo;analyse, multiplexage et g\u00e9n\u00e9ration de donn\u00e9es cin\u00e9tiques. L&rsquo;adoption du syst\u00e8me IncuCyte\u00ae ZOOM a renforc\u00e9 l&rsquo;expertise de Sygnature en recherche dans de nombreux domaines th\u00e9rapeutiques, notamment l&rsquo;oncologie, l&rsquo;immunologie, l&rsquo;inflammation et les neurosciences.  <\/p>\n<p>Les tests IncuCyte\u00ae ZOOM d\u00e9j\u00e0 disponibles chez Sygnature comprennent&nbsp;:<\/p>\n<ul>\n<li>Migration et invasion cellulaires\n<ul>\n<li>Quantification en temps r\u00e9el de la migration cellulaire \u00e0 travers un rev\u00eatement plastique ou biomatrice<\/li>\n<li>\u00c9valuation des effets du traitement combin\u00e9 sur les profils de migration au cours du temps complet<\/li>\n<\/ul>\n<\/li>\n<li>Angiogen\u00e8se\n<ul>\n<li>Mesures cin\u00e9tiques de la formation de tubes vasculaires utilisant des mod\u00e8les de co-culture de cellules endoth\u00e9liales\/fibroblastes (d\u00e9monstration des phases de prolif\u00e9ration, de migration, de diff\u00e9renciation et d&rsquo;anastomose)<\/li>\n<\/ul>\n<\/li>\n<li>Prolif\u00e9ration, cytotoxicit\u00e9 et apoptose\n<ul>\n<li>Mesures en temps r\u00e9el de cellules vivantes<\/li>\n<\/ul>\n<\/li>\n<li>Applications en immuno-oncologie\n<ul>\n<li>Y compris les tests de destruction des cellules T cytotoxiques et les tests de cytotoxicit\u00e9 cellulaire d\u00e9pendante des anticorps (ADCC)<\/li>\n<\/ul>\n<\/li>\n<li>\u00c9tudes neuronales\n<ul>\n<li>Mesure et quantification sans marquage de la dynamique des neurites en temps r\u00e9el (longueur, ramification et r\u00e9traction des neurites, nombre de corps cellulaires). <\/li>\n<\/ul>\n<\/li>\n<li>Biologie 3D :\n<ul>\n<li>Surveillance en temps r\u00e9el de la formation et de la croissance des sph\u00e9ro\u00efdes<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Commentant l&rsquo;int\u00e9gration du syst\u00e8me IncuCyte\u00ae ZOOM au sein du d\u00e9partement de biosciences de Sygnature, le Dr Simon Hirst, fondateur et PDG de Sygnature, a d\u00e9clar\u00e9&nbsp;: \u00ab&nbsp;Afin de conserver notre position de leader dans la d\u00e9couverte int\u00e9gr\u00e9e de m\u00e9dicaments, Sygnature \u00e9value constamment les nouvelles technologies et les alliances strat\u00e9giques qui renforcent et compl\u00e8tent nos capacit\u00e9s. L&rsquo;alliance strat\u00e9gique avec Essen BioScience s&rsquo;est av\u00e9r\u00e9e tr\u00e8s fructueuse pour les deux parties. Nous avons \u00e9t\u00e9 tellement impressionn\u00e9s par IncuCyte\u00ae que nous avons investi dans cette technologie et dans la formation n\u00e9cessaire \u00e0 son d\u00e9veloppement. De nombreux projets de recherche ont d\u00e9j\u00e0 b\u00e9n\u00e9fici\u00e9 des donn\u00e9es d&rsquo;imagerie de haute qualit\u00e9 que nous g\u00e9n\u00e9rons. Sygnature propose son expertise en imagerie cellulaire en temps r\u00e9el, qui apporte une r\u00e9elle valeur ajout\u00e9e, soit de mani\u00e8re ind\u00e9pendante, soit dans le cadre d&rsquo;une collaboration int\u00e9gr\u00e9e pour la d\u00e9couverte de m\u00e9dicaments.&nbsp;\u00bb<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":13913,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"category":[790,29,843],"tags":[],"class_list":["post-13911","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bioscience","category-non-categorise","category-tests-cellulaires"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>L&#039;adoption d&#039;IncuCyte\u00ae ZOOM renforce les capacit\u00e9s de Syngnature Discovery. - 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