{"id":13643,"date":"2023-09-25T15:20:49","date_gmt":"2023-09-25T15:20:49","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/sygnature-discovery-et-ube-corporation-ont-identifie-avec-succes-des-composes-degradeurs-puissants-de-shp2\/"},"modified":"2026-02-11T09:42:36","modified_gmt":"2026-02-11T09:42:36","slug":"sygnature-discovery-et-ube-corporation-ont-identifie-avec-succes-des-composes-degradeurs-puissants-de-shp2","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-et-ube-corporation-ont-identifie-avec-succes-des-composes-degradeurs-puissants-de-shp2\/","title":{"rendered":"Sygnature Discovery et UBE Corporation ont identifi\u00e9 avec succ\u00e8s des compos\u00e9s d\u00e9gradeurs puissants de SHP2"},"content":{"rendered":"<h4><span class=\"ui-provider ed bmr bms bmt bmu bmv bmw bmx bmy bmz bna bnb bnc bnd bne bnf bng bnh bni bnj bnk bnl bnm bnn bno bnp bnq bnr bns bnt bnu bnv bnw bnx bny\" dir=\"ltr\">Sygnature Discovery identifie de puissants compos\u00e9s d\u00e9gradeurs de SHP2 gr\u00e2ce \u00e0 sa plateforme exclusive de d\u00e9gradation cibl\u00e9e des prot\u00e9ines, CHARMED, en collaboration avec la soci\u00e9t\u00e9 japonaise de chimie de sp\u00e9cialit\u00e9 UBE Corporation.<\/span><\/h4>\n<p>\u00a0<\/p>\n<p><span style=\"font-size: 14pt;\">Sygnature Discovery et UBE Corporation ont entam\u00e9 une collaboration dans le cadre d\u2019un programme de criblage de compos\u00e9s candidats pour identifier des d\u00e9gradeurs de SHP2. SHP2 est une phosphatase sp\u00e9cifique de la tyrosine impliqu\u00e9e dans les cancers humains, et l\u2019objectif est de d\u00e9velopper des compos\u00e9s bifonctionnels puissants pr\u00e9sentant d\u2019excellentes propri\u00e9t\u00e9s ADME et PK pour une d\u00e9gradation efficace de SHP2. <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">Gr\u00e2ce \u00e0 cette collaboration, les \u00e9quipes ont d\u00e9couvert des compos\u00e9s actifs uniques (profil : DC50 \u00e0 un chiffre nM et Dmax d\u2019environ 100 %) en utilisant la plateforme technologique exclusive et innovante CHARMED de Sygnature Discovery.<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">La plateforme <a href=\"https:\/\/info.sygnaturediscovery.com\/charmed-from-sygnature-discovery\">CHARMED<\/a> a \u00e9t\u00e9 d\u00e9velopp\u00e9e par Sygnature Discovery pour permettre la synth\u00e8se, le criblage et la caract\u00e9risation rapides de compos\u00e9s bifonctionnels prometteurs. Pour ce faire, CHARMED utilise des plaques pr\u00eates \u00e0 coupler de divers connecteurs et de t\u00eates de ligase populaires en combinaison avec des approches de biologie \u00e0 haut d\u00e9bit, acc\u00e9l\u00e9rant l\u2019identification de cibles d\u00e9gradantes pour de nouvelles cibles.<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">Les d\u00e9gradeurs bifonctionnels agissent par proximit\u00e9 induite d\u2019une ubiquitine-ligase, en s\u2019appuyant sur l\u2019acc\u00e8s \u00e0 des compos\u00e9s se liant \u00e0 la cible d\u2019int\u00e9r\u00eat. Ces compos\u00e9s peuvent \u00eatre identifi\u00e9s par des m\u00e9thodes d\u2019affinit\u00e9 telles que FBDD, ASMS ou le criblage DEL et utilis\u00e9s dans CHARMED pour \u00e9valuer rapidement l\u2019activit\u00e9 des compos\u00e9s d\u00e9gradeurs sur de nouvelles cibles. <\/span><\/p>\n<h2><span style=\"font-size: 14pt;\"><a href=\"https:\/\/www.sygnaturediscovery.com\/team-members\/dr-simon-hirst\/\">Simon Hirst<\/a> , PDG de Sygnature Discovery, d\u00e9clare :<\/span><\/h2>\n<p><span style=\"font-size: 14pt;\">Les propri\u00e9t\u00e9s physiques de la d\u00e9gradation cibl\u00e9e des prot\u00e9ines et des mol\u00e9cules bifonctionnelles sont atypiques par rapport au d\u00e9veloppement classique des petites mol\u00e9cules, car elles ne suivent pas la r\u00e8gle des cinq. Il nous faut donc des technologies capables d\u2019\u00e9valuer et de filtrer ces propri\u00e9t\u00e9s afin de s\u00e9lectionner les mol\u00e9cules les plus prometteuses. La d\u00e9gradation cibl\u00e9e des prot\u00e9ines et les mol\u00e9cules bifonctionnelles de ce type suscitent un vif int\u00e9r\u00eat, mais de nombreux chercheurs peinent \u00e0 identifier des points de d\u00e9part dans leurs programmes de recherche ou des mol\u00e9cules poss\u00e9dant les propri\u00e9t\u00e9s requises pour r\u00e9ussir en clinique.  <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u00ab Nous sommes ravis de soutenir le travail d\u2019UBE Corporation. Notre plateforme CHARMED associe des capacit\u00e9s de chimie \u00e0 haut d\u00e9bit \u00e0 une biologie \u00e0 haut d\u00e9bit\u00a0; nous soutenons donc la synth\u00e8se rapide de mol\u00e9cules bifonctionnelles gr\u00e2ce \u00e0 une s\u00e9rie de tests et de plateformes qui permettront d\u2019\u00e9valuer leur potentiel pour la suite du d\u00e9veloppement. \u00bb<\/span><\/p>\n<h3><\/h3>\n<p>\u00a0<\/p>\n<h3>\u00c0 propos de Sygnature Discovery<\/h3>\n<p><span style=\"font-size: 14pt;\">Sygnature Discovery est une soci\u00e9t\u00e9 de recherche contractuelle (CRO) de premier plan sp\u00e9cialis\u00e9e dans la d\u00e9couverte de m\u00e9dicaments, implant\u00e9e au Royaume-Uni et au Canada. Son si\u00e8ge social se trouve \u00e0 Nottingham et elle poss\u00e8de des sites \u00e0 Alderley Park, Macclesfield, Glasgow, Montr\u00e9al et Qu\u00e9bec. Forte de plus de 1\u00a0000 employ\u00e9s, dont plus de 900 scientifiques, elle collabore avec des entreprises pharmaceutiques, biotechnologiques et des organismes sans but lucratif du monde entier. <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">Depuis 2011, Sygnature Discovery a d\u00e9velopp\u00e9 plus de 40 nouveaux compos\u00e9s pr\u00e9cliniques et 22 compos\u00e9s cliniques, et ses scientifiques sont signataires de plus de 170 brevets. Ses domaines d\u2019expertise th\u00e9rapeutique comprennent l\u2019oncologie, l\u2019inflammation et l\u2019immunologie, les neurosciences, les maladies m\u00e9taboliques, les maladies infectieuses, les maladies fibrotiques et bien d\u2019autres. <\/span><\/p>\n<p>\u00a0<\/p>\n<h3><span style=\"font-size: 14pt;\"><strong><img decoding=\"async\" class=\"size-full wp-image-15702 alignleft\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/UBE_logo.jpg\" alt=\"\"><\/strong>\u00c0 propos d\u2019UBE Corporation<\/span><\/h3>\n<p><span style=\"font-size: 14pt;\">UBE Corporation regroupe plusieurs entreprises de chimie de sp\u00e9cialit\u00e9, dont l\u2019activit\u00e9 pharmaceutique constitue le c\u0153ur de son portefeuille en sciences de la vie. Forte de son exp\u00e9rience en mati\u00e8re de d\u00e9couvertes de petites mol\u00e9cules th\u00e9rapeutiques, elle d\u00e9veloppe d\u00e9sormais des produits \u00e0 forte valeur ajout\u00e9e tels que les ADC (conjugu\u00e9s anticorps-m\u00e9dicament) et les d\u00e9gradeurs bifonctionnels. Parall\u00e8lement, son activit\u00e9 de CDMO (organisation de d\u00e9veloppement et de fabrication \u00e0 fa\u00e7on) renforce ses capacit\u00e9s de production de petites mol\u00e9cules tout en acqu\u00e9rant des comp\u00e9tences dans de nouvelles modalit\u00e9s th\u00e9rapeutiques, comme les oligonucl\u00e9otides th\u00e9rapeutiques. Les activit\u00e9s d\u2019UBE Corporation dans le domaine des sciences de la vie continueront de proposer des solutions qui am\u00e9liorent et prot\u00e8gent la vie et la sant\u00e9 humaines.  <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">Soci\u00e9t\u00e9 UBE :<\/span><\/p>\n<p><a href=\"https:\/\/www.ube.com\/contents\/en\/index.html\" target=\"_blank\" rel=\"noopener\">Page d\u2019accueil de l\u2019entreprise<\/a><\/p>\n<p><a href=\"https:\/\/www.ube.com\/contents\/en\/chemical\/pharmaceutical\/index.html\" target=\"_blank\" rel=\"noopener\">Page d\u2019accueil pharmaceutique<\/a><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":13645,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"category":[819,821,820,823,822],"tags":[835,826,831,824,825,829,840,837,838,827,834,836,830,839,841,828,833,832,842],"class_list":["post-13643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-decouverte-integree-de-medicaments","category-hit-pour-devenir-leader","category-modalites","category-oncologie","category-tpd","tag-biologie-a-haut-debit","tag-collaboration","tag-composes-bifonctionnels","tag-decouverte-de-la-signature","tag-decouverte-de-medicaments","tag-degradation-ciblee-des-proteines","tag-degradeurs-shp2","tag-immunologie","tag-inflammation","tag-oncologie","tag-organisation-de-recherche-sous-contrat","tag-programme-hit-to-lead","tag-proprietes-adme","tag-proprietes-pk","tag-societe-ube","tag-synthese-rapide","tag-technologie-charmed","tag-traitement-du-cancer","tag-ubiquitine-ligase"],"acf":[],"yoast_head":"<!-- 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