{"id":13642,"date":"2024-09-26T09:28:48","date_gmt":"2024-09-26T09:28:48","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/sygnature-discovery-ouvre-la-voie-a-des-traitements-revolutionnaires-grace-a-une-nouvelle-plateforme-de-modelisation-des-maladies-humaines\/"},"modified":"2026-02-11T09:43:48","modified_gmt":"2026-02-11T09:43:48","slug":"sygnature-discovery-ouvre-la-voie-a-des-traitements-revolutionnaires-grace-a-une-nouvelle-plateforme-de-modelisation-des-maladies-humaines","status":"publish","type":"post","link":"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-ouvre-la-voie-a-des-traitements-revolutionnaires-grace-a-une-nouvelle-plateforme-de-modelisation-des-maladies-humaines\/","title":{"rendered":"Sygnature Discovery ouvre la voie \u00e0 des traitements r\u00e9volutionnaires gr\u00e2ce \u00e0 une nouvelle plateforme de mod\u00e9lisation des maladies humaines"},"content":{"rendered":"<p><span style=\"font-size: 18pt;\"><strong>Sygnature Discovery a d\u00e9voil\u00e9 sa plateforme <em>in vitro<\/em> humanis\u00e9e de neuroinflammation, SCANME (SCreening for Anti-Neuroinflammation Molecular Entities), con\u00e7ue pour \u00e9tendre la mod\u00e9lisation des maladies humaines et repousser les limites du traitement des affections neuro-inflammatoires invalidantes telles que la maladie d&rsquo;Alzheimer.<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 14pt;\"><img decoding=\"async\" class=\"size-medium wp-image-17760 aligncenter\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/SCANME-POSTER-FRAME.jpg\" alt=\"\"><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 14pt;\">Les maladies neurod\u00e9g\u00e9n\u00e9ratives caus\u00e9es par la neuroinflammation constituent un probl\u00e8me de sant\u00e9 publique majeur \u00e0 l&rsquo;\u00e9chelle mondiale. Or, le processus de d\u00e9veloppement des m\u00e9dicaments est notoirement lent et les taux d&rsquo;\u00e9chec clinique d\u00e9passent les 96 %. Par exemple, le premier m\u00e9dicament ciblant l&rsquo;hypoth\u00e8se amylo\u00efde dans la maladie d&rsquo;Alzheimer n&rsquo;a \u00e9t\u00e9 approuv\u00e9 aux \u00c9tats-Unis que l&rsquo;ann\u00e9e derni\u00e8re, apr\u00e8s 40 ans de recherche et d\u00e9veloppement. <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">Pour relever ces d\u00e9fis, SCANME exploite les cellules souches pluripotentes induites humaines (iPSC), d\u00e9riv\u00e9es de cellules somatiques, afin d&rsquo;offrir des connaissances biologiquement pertinentes qui renforcent la confiance dans la transposition clinique et contribuent \u00e0 \u00ab humaniser \u00bb la d\u00e9couverte de m\u00e9dicaments.<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">SCANME fournit un mod\u00e8le de maladie \u00e9volutif et pertinent pour l&rsquo;homme qui produit des donn\u00e9es robustes et reproductibles, acc\u00e9l\u00e9rant ainsi le passage de la d\u00e9couverte de compos\u00e9s aux connaissances cliniques.<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">L&rsquo;un des atouts majeurs de SCANME r\u00e9side dans l&rsquo;int\u00e9gration de l&rsquo;imagerie \u00e0 haut contenu (HCI), qui permet de capturer simultan\u00e9ment de multiples param\u00e8tres lors de la mod\u00e9lisation des maladies, enrichissant ainsi la compr\u00e9hension biologique. De plus, la flexibilit\u00e9 et l&rsquo;\u00e9volutivit\u00e9 de la plateforme offrent un large \u00e9ventail d&rsquo;options personnalisables pour r\u00e9pondre aux divers besoins de recherche. <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">Max Mirza, vice-pr\u00e9sident de la d\u00e9couverte de m\u00e9dicaments en neurosciences, a d\u00e9clar\u00e9 : \u00ab <a href=\"https:\/\/info.sygnaturediscovery.com\/scanme\"><strong>La plateforme SCANME de Sygnature Discovery<\/strong><\/a> est \u00e0 la pointe de la d\u00e9couverte de m\u00e9dicaments en permettant aux chercheurs d&rsquo;\u00e9tendre l&rsquo;application de cellules d\u00e9riv\u00e9es de cellules iPSC humaines sp\u00e9cialis\u00e9es, en particulier la microglie, qui est essentielle pour la recherche sur la neuroinflammation.<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u00ab Nous sommes attach\u00e9s \u00e0 l\u2019innovation continue et \u00e0 l\u2019investissement dans les technologies appropri\u00e9es afin de rester \u00e0 la pointe du progr\u00e8s, en apportant de nouvelles possibilit\u00e9s et des avanc\u00e9es \u00e0 notre offre \u00e9largie en neurosciences pour nos clients. \u00bb<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u00ab Notre collaboration avec Axol Bioscience, leader dans la production de cellules iPSC humaines fonctionnellement pertinentes, nous permet de fournir des cellules et un soutien technique de la plus haute qualit\u00e9. Ce partenariat allie une expertise in\u00e9gal\u00e9e et des approches novatrices pour optimiser les r\u00e9sultats de la recherche. \u00bb <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u00ab La solide expertise de Sygnature en recherche en neurosciences garantit une compr\u00e9hension approfondie des enjeux et des exigences du domaine. La plateforme SCANME offre une personnalisation in\u00e9gal\u00e9e, une imagerie avanc\u00e9e, une expertise pointue et une grande \u00e9volutivit\u00e9. \u00bb<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 18pt;\"><strong>\u00c0 propos de Sygnature Discovery<\/strong><\/span><\/p>\n<p><span style=\"font-size: 18pt;\">Sygnature Discovery est une organisation de recherche contractuelle int\u00e9gr\u00e9e de premier plan dans le domaine de la d\u00e9couverte de m\u00e9dicaments, bas\u00e9e au Royaume-Uni et au Canada, avec son si\u00e8ge social \u00e0 Nottingham (Royaume-Uni). D&rsquo;autres sites sont situ\u00e9s \u00e0 Alderley Park, Macclesfield et Glasgow (Royaume-Uni), ainsi qu&rsquo;\u00e0 Montr\u00e9al et Qu\u00e9bec (Canada). Son \u00e9quipe de plus de 1 000 employ\u00e9s, dont 900 scientifiques, collabore avec des entreprises pharmaceutiques, biotechnologiques et des organisations \u00e0 but non lucratif du monde entier. Depuis 2011, Sygnature Discovery a mis au point plus de 40 nouveaux compos\u00e9s pr\u00e9cliniques et 25 compos\u00e9s cliniques, et ses scientifiques sont cit\u00e9s dans plus de 170 brevets. Ses domaines d&rsquo;expertise th\u00e9rapeutique comprennent l&rsquo;oncologie, l&rsquo;inflammation et l&rsquo;immunologie, les neurosciences, les maladies m\u00e9taboliques, les maladies infectieuses, les maladies fibrotiques, et bien plus encore.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 18pt;\"><span style=\"color: #00ccff;\"><strong>Venez rencontrer Sygnature Discovery \u00e0 la conf\u00e9rence Neuroscience 2024 de la SfN \u00e0 Chicago (du 5 au 9 octobre), stand<\/strong><\/span> <span style=\"color: #00ccff;\"><strong>n\u00b0 633<\/strong><\/span><\/span><\/p>\n<p><span style=\"font-size: 18pt;\"><span style=\"color: #00ccff;\"><strong><img decoding=\"async\" class=\"size-medium wp-image-17724 aligncenter\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/neuroscience-2024.png\" alt=\"\"><br \/>\n<\/strong><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":13644,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"category":[817,818],"tags":[],"class_list":["post-13642","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-domaines-therapeutiques","category-neuroscience"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sygnature Discovery ouvre la voie \u00e0 des traitements r\u00e9volutionnaires gr\u00e2ce \u00e0 une nouvelle plateforme de mod\u00e9lisation des maladies humaines - Sygnature<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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