{"id":4221,"date":"2025-11-16T08:00:12","date_gmt":"2025-11-16T08:00:12","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/"},"modified":"2026-04-03T14:53:51","modified_gmt":"2026-04-03T14:53:51","slug":"a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/","title":{"rendered":"A Human iPSC-Derived Motor Neuron Platform: Applications for Drug Discovery and ALS Research"},"content":{"rendered":"

Recreating ALS pathology in vitro<\/em> to uncover tomorrow\u2019s treatments<\/strong><\/span><\/p>\n

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with limited therapeutic options and a high clinical failure rate. To address this, we\u2019ve developed a human iPSC-derived motor neuron platform, in collaboration with Axol Bioscience<\/a>, with validated ALS-relevant assays reflecting key pathophysiological features, including mitochondrial dysfunction.<\/span><\/p>\n

Our scalable platform enables high-throughput drug screening and target validation in 96- and 384-well formats. We demonstrate phenotypic differences between motor neurons from ALS patients and healthy donors and outline future directions using stressors to model multi-step disease progression.<\/span><\/p>\n

<\/strong> Download the poster to see how this platform accelerates ALS drug discovery through functional, human-relevant models.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":8364,"template":"","category":[681,709,708,753,689,688],"class_list":["post-4221","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-cell-based-assays","category-high-throughput-screening","category-neuroscience","category-target-identification-and-validation","category-therapeutic-areas"],"acf":[],"yoast_head":"\nA Human iPSC-Derived Motor Neuron Platform: Applications for Drug Discovery and ALS Research - Sygnature<\/title>\n<meta name=\"description\" content=\"Discover a high-content imaging platform using patient fibroblasts to assess lysosomal dysfunction in Alzheimer\u2019s and Parkinson\u2019s disease. Download the scientific poster.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Human iPSC-Derived Motor Neuron Platform: Applications for Drug Discovery and ALS Research - Sygnature\" \/>\n<meta property=\"og:description\" content=\"Discover a high-content imaging platform using patient fibroblasts to assess lysosomal dysfunction in Alzheimer\u2019s and Parkinson\u2019s disease. Download the scientific poster.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-03T14:53:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Human-Motor-Neuron-Poster_SfN-2025_Final_MKT-noQR-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1822\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\\\/\",\"name\":\"A Human iPSC-Derived Motor Neuron Platform: Applications for Drug Discovery and ALS Research - Sygnature\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/Human-Motor-Neuron-Poster_SfN-2025_Final_MKT-noQR-scaled.jpg\",\"datePublished\":\"2025-11-16T08:00:12+00:00\",\"dateModified\":\"2026-04-03T14:53:51+00:00\",\"description\":\"Discover a high-content imaging platform using patient fibroblasts to assess lysosomal dysfunction in Alzheimer\u2019s and Parkinson\u2019s disease. Download the scientific poster.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/Human-Motor-Neuron-Poster_SfN-2025_Final_MKT-noQR-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/Human-Motor-Neuron-Poster_SfN-2025_Final_MKT-noQR-scaled.jpg\",\"width\":2560,\"height\":1822},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/page-daccueil\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A Human iPSC-Derived Motor Neuron Platform: Applications for Drug Discovery and ALS Research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"name\":\"Sygnature Discovery\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\"},\"alternateName\":\"Sygnature\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\",\"name\":\"Sygnature\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Sygnature\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A Human iPSC-Derived Motor Neuron Platform: Applications for Drug Discovery and ALS Research - Sygnature","description":"Discover a high-content imaging platform using patient fibroblasts to assess lysosomal dysfunction in Alzheimer\u2019s and Parkinson\u2019s disease. Download the scientific poster.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/","og_locale":"fr_CA","og_type":"article","og_title":"A Human iPSC-Derived Motor Neuron Platform: Applications for Drug Discovery and ALS Research - Sygnature","og_description":"Discover a high-content imaging platform using patient fibroblasts to assess lysosomal dysfunction in Alzheimer\u2019s and Parkinson\u2019s disease. Download the scientific poster.","og_url":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/","og_site_name":"Sygnature","article_modified_time":"2026-04-03T14:53:51+00:00","og_image":[{"width":2560,"height":1822,"url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Human-Motor-Neuron-Poster_SfN-2025_Final_MKT-noQR-scaled.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimation du temps de lecture":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/","url":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/","name":"A Human iPSC-Derived Motor Neuron Platform: Applications for Drug Discovery and ALS Research - Sygnature","isPartOf":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/#primaryimage"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Human-Motor-Neuron-Poster_SfN-2025_Final_MKT-noQR-scaled.jpg","datePublished":"2025-11-16T08:00:12+00:00","dateModified":"2026-04-03T14:53:51+00:00","description":"Discover a high-content imaging platform using patient fibroblasts to assess lysosomal dysfunction in Alzheimer\u2019s and Parkinson\u2019s disease. Download the scientific poster.","breadcrumb":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/#primaryimage","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Human-Motor-Neuron-Poster_SfN-2025_Final_MKT-noQR-scaled.jpg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Human-Motor-Neuron-Poster_SfN-2025_Final_MKT-noQR-scaled.jpg","width":2560,"height":1822},{"@type":"BreadcrumbList","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-human-ipsc-derived-motor-neuron-platform-applications-for-drug-discovery-and-als-research\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sygnaturediscovery.com\/fr\/page-daccueil\/"},{"@type":"ListItem","position":2,"name":"A Human iPSC-Derived Motor Neuron Platform: Applications for Drug Discovery and ALS Research"}]},{"@type":"WebSite","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","name":"Sygnature Discovery","description":"","publisher":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization"},"alternateName":"Sygnature","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sygnaturediscovery.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"},{"@type":"Organization","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization","name":"Sygnature","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","width":1,"height":1,"caption":"Sygnature"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/poster\/4221","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/poster"}],"about":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/types\/poster"}],"version-history":[{"count":0,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/poster\/4221\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media\/8364"}],"wp:attachment":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media?parent=4221"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/category?post=4221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}