{"id":4219,"date":"2025-11-18T08:00:03","date_gmt":"2025-11-18T08:00:03","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/a-high-content-multiplex-platform-for-investigating-lysosomal-dysfunction-in-patient-derived-fibroblasts-applications-in-neurodegeneration-drug-discovery\/"},"modified":"2026-04-03T14:52:59","modified_gmt":"2026-04-03T14:52:59","slug":"a-high-content-multiplex-platform-for-investigating-lysosomal-dysfunction-in-patient-derived-fibroblasts-applications-in-neurodegeneration-drug-discovery","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/a-high-content-multiplex-platform-for-investigating-lysosomal-dysfunction-in-patient-derived-fibroblasts-applications-in-neurodegeneration-drug-discovery\/","title":{"rendered":"A High-Content, Multiplex Platform for Investigating Lysosomal Dysfunction in Patient-Derived Fibroblasts: Applications in Neurodegeneration Drug Discovery"},"content":{"rendered":"

A Scalable Platform for Decoding Lysosomal Dysfunction in Neurodegenerative Disease<\/span><\/h2>\n

Mapping Cellular Defects to Drug Discovery<\/span><\/h3>\n

Lysosomal dysfunction is a key hallmark in neurodegenerative diseases like Alzheimer\u2019s and Parkinson\u2019s. But translating this biology into drug discovery demands robust, human-relevant models.<\/span><\/p>\n

In this study, we present a high-content, multiplexed imaging platform using patient-derived fibroblasts to assess lysosomal integrity, autophagic flux, and rescue potential.<\/span><\/p>\n

Our semi-automated system delivers scalable, quantitative phenotyping\u2014ideal for screening compounds that modulate lysosomal function in disease-relevant contexts.<\/span><\/p>\n

Download the free poster to explore how this platform bridges human pathology and early-stage neuroscience drug discovery.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":8334,"template":"","category":[681,709,753,688],"class_list":["post-4219","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-cell-based-assays","category-neuroscience","category-therapeutic-areas"],"acf":[],"yoast_head":"\nA High-Content, Multiplex Platform for Investigating Lysosomal Dysfunction in Patient-Derived Fibroblasts: Applications in Neurodegeneration Drug Discovery - Sygnature<\/title>\n<meta name=\"description\" content=\"Discover a high-content imaging platform using patient fibroblasts to assess lysosomal dysfunction in Alzheimer\u2019s and Parkinson\u2019s disease. 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