{"id":4217,"date":"2026-04-08T15:00:14","date_gmt":"2026-04-08T15:00:14","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/"},"modified":"2026-04-08T15:00:15","modified_gmt":"2026-04-08T15:00:15","slug":"lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/","title":{"rendered":"LRRK2 Degrader Discovery: A High-Throughput Direct-to-Biology Screening Platform"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\">Accelerating <a href=\"https:\/\/www.sygnaturediscovery.com\/therapeutic-areas\/neuroscience\/\">CNS Drug Discovery<\/a> with a Direct-to-Biology Platform<\/h2>\n\n\n\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Parkinson\u2019s Disease (PD) is a growing global concern, with LRRK2 emerging as a key therapeutic target. In this study, we showcase a novel high-throughput Direct-to-Biology platform to discover potent degraders against LRRK2 kinase, offering a valuable alternative to traditional kinase inhibition.<\/span><\/p>\n\n\n\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Our flexible and scalable approach enabled rapid synthesis and evaluation of bifunctional LRRK2 degraders, identifying several compounds with nanomolar potency, ready for validation in neurologically relevant systems.<\/span><\/p>\n\n\n\n<p class=\"has-text-lg-font-size\"><span style=\"font-family: arial, helvetica, sans-serif;\">Download the free poster to explore how our Direct-to-Biology platform can be applied to neurodegenerative drug discovery beyond LRRK2.<\/span><\/p>\n\n\n\n<p class=\"has-text-sm-font-size\">References:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li class=\"has-text-sm-font-size\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c05499\" type=\"link\" id=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c05499\">Liu, X., <em>et al.<\/em>, Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood\u2013Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. J. Am. Chem. Soc. 2022, 144, 16930\u201316952.<\/a><\/li>\n\n\n\n<li class=\"has-text-sm-font-size\"><a href=\"https:\/\/patents.google.com\/patent\/WO2022198112A1\/en\">Araujo, E., <em>et al.<\/em>, Indazole Based Compounds and Associated Methods of Use. U.S. Patent No. WO2022198112A1, 22 September 2022<\/a><\/li>\n\n\n\n<li class=\"has-text-sm-font-size\"><a href=\"https:\/\/patents.google.com\/patent\/US11858940B2\/en\">Araujo, E., <em>et al.<\/em>, Selective Modulators of Mutant LRRK2 Proteolysis and Associated Methods of Use. U.S. Patent No. US11858940B2, 2 January 2024.<\/a><\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><span style=\"font-family: arial, helvetica, sans-serif;\" data-teams=\"true\">&nbsp;<\/span><\/h3>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":16671,"template":"","category":[681,1402,708,690,686,753,687,688,743],"class_list":["post-4217","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-direct-to-biology","category-high-throughput-screening","category-hit-identification","category-modalities","category-neuroscience","category-target-classes","category-therapeutic-areas","category-tpd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>High-Throughput Direct-to-Biology LRRK2 Degrader Platform<\/title>\n<meta name=\"description\" content=\"Explore how our direct-to-biology screening platform accelerates LRRK2 degrader discovery. Download the full poster and see the data.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-Throughput Direct-to-Biology LRRK2 Degrader Platform\" \/>\n<meta property=\"og:description\" content=\"Explore how our direct-to-biology screening platform accelerates LRRK2 degrader discovery. Download the full poster and see the data.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-08T15:00:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"724\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\\\/\",\"name\":\"High-Throughput Direct-to-Biology LRRK2 Degrader Platform\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform.webp\",\"datePublished\":\"2026-04-08T15:00:14+00:00\",\"dateModified\":\"2026-04-08T15:00:15+00:00\",\"description\":\"Explore how our direct-to-biology screening platform accelerates LRRK2 degrader discovery. Download the full poster and see the data.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform.webp\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform.webp\",\"width\":1024,\"height\":724,\"caption\":\"Feature image showing a scientific poster on a direct\u2011to\u2011biology screening platform for LRRK2 degrader discovery, including workflow diagrams, assay data and degradation results.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/page-daccueil\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"LRRK2 Degrader Discovery: A High-Throughput Direct-to-Biology Screening Platform\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"name\":\"Sygnature Discovery\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\"},\"alternateName\":\"Sygnature\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\",\"name\":\"Sygnature\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Sygnature\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"High-Throughput Direct-to-Biology LRRK2 Degrader Platform","description":"Explore how our direct-to-biology screening platform accelerates LRRK2 degrader discovery. Download the full poster and see the data.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/","og_locale":"fr_CA","og_type":"article","og_title":"High-Throughput Direct-to-Biology LRRK2 Degrader Platform","og_description":"Explore how our direct-to-biology screening platform accelerates LRRK2 degrader discovery. Download the full poster and see the data.","og_url":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/","og_site_name":"Sygnature","article_modified_time":"2026-04-08T15:00:15+00:00","og_image":[{"width":1024,"height":724,"url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform.webp","type":"image\/webp"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimation du temps de lecture":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/","url":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/","name":"High-Throughput Direct-to-Biology LRRK2 Degrader Platform","isPartOf":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/#primaryimage"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform.webp","datePublished":"2026-04-08T15:00:14+00:00","dateModified":"2026-04-08T15:00:15+00:00","description":"Explore how our direct-to-biology screening platform accelerates LRRK2 degrader discovery. Download the full poster and see the data.","breadcrumb":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/#primaryimage","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform.webp","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform.webp","width":1024,"height":724,"caption":"Feature image showing a scientific poster on a direct\u2011to\u2011biology screening platform for LRRK2 degrader discovery, including workflow diagrams, assay data and degradation results."},{"@type":"BreadcrumbList","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sygnaturediscovery.com\/fr\/page-daccueil\/"},{"@type":"ListItem","position":2,"name":"LRRK2 Degrader Discovery: A High-Throughput Direct-to-Biology Screening Platform"}]},{"@type":"WebSite","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","name":"Sygnature Discovery","description":"","publisher":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization"},"alternateName":"Sygnature","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sygnaturediscovery.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"},{"@type":"Organization","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization","name":"Sygnature","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","width":1,"height":1,"caption":"Sygnature"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/poster\/4217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/poster"}],"about":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/types\/poster"}],"version-history":[{"count":0,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/poster\/4217\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media\/16671"}],"wp:attachment":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media?parent=4217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/category?post=4217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}