{"id":4211,"date":"2025-11-16T08:00:41","date_gmt":"2025-11-16T08:00:41","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/evaluation-of-two-novel-compounds-compared-to-methadone-on-morphine-withdrawal-in-a-rat-model-of-physical-dependence\/"},"modified":"2026-04-03T14:53:26","modified_gmt":"2026-04-03T14:53:26","slug":"evaluation-of-two-novel-compounds-compared-to-methadone-on-morphine-withdrawal-in-a-rat-model-of-physical-dependence","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/evaluation-of-two-novel-compounds-compared-to-methadone-on-morphine-withdrawal-in-a-rat-model-of-physical-dependence\/","title":{"rendered":"Evaluation of Two Novel Compounds Compared to Methadone on Morphine Withdrawal in a Rat Model of Physical dependence"},"content":{"rendered":"<p data-start=\"312\" data-end=\"388\"><span style=\"font-family: arial, helvetica, sans-serif;\"><strong data-start=\"312\" data-end=\"388\">Exploring Safer Alternatives to Methadone for Opioid Maintenance Therapy<\/strong><\/span><\/p>\n<p data-start=\"390\" data-end=\"664\"><span style=\"font-family: arial, helvetica, sans-serif;\">Methadone remains a cornerstone of opioid maintenance therapy (OMT), but its use comes with safety and compliance challenges. This study, conducted with <a href=\"https:\/\/ensysce.com\/\">Ensysce Biosciences<\/a>, evaluates two novel compounds (<strong data-start=\"594\" data-end=\"615\">PF9110 and PF9201<\/strong>) in a <strong data-start=\"621\" data-end=\"663\">preclinical model of opioid dependence<\/strong>.<\/span><\/p>\n<p data-start=\"666\" data-end=\"879\"><span style=\"font-family: arial, helvetica, sans-serif;\">The results? Both compounds alleviated key withdrawal symptoms <strong data-start=\"729\" data-end=\"771\">without inducing opioid-like behaviors<\/strong>, highlighting their potential as safer alternatives to methadone in treating <strong data-start=\"849\" data-end=\"879\">opioid use disorder (OUD).<\/strong><\/span><\/p>\n<p data-start=\"881\" data-end=\"988\"><span style=\"font-family: arial, helvetica, sans-serif;\">  <strong data-start=\"884\" data-end=\"912\">Download the free poster<\/strong> to review the full data and insights from this comparative rat model study.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":8437,"template":"","category":[735,685,753,688],"class_list":["post-4211","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-cns-pain-models","category-in-vivo-pharmacology","category-neuroscience","category-therapeutic-areas"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Evaluation of Two Novel Compounds Compared to Methadone on Morphine Withdrawal in a Rat Model of Physical dependence - Sygnature<\/title>\n<meta name=\"description\" content=\"Explore how PF9110 and PF9201 compare to methadone in a rat model of opioid dependence. 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