{"id":4209,"date":"2025-10-16T13:28:29","date_gmt":"2025-10-16T13:28:29","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/strategies-for-tackling-challenging-membrane-protein-targets\/"},"modified":"2026-01-22T13:20:51","modified_gmt":"2026-01-22T13:20:51","slug":"strategies-for-tackling-challenging-membrane-protein-targets","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/strategies-for-tackling-challenging-membrane-protein-targets\/","title":{"rendered":"Strategies for Tackling Challenging Membrane Protein Targets"},"content":{"rendered":"<p data-start=\"183\" data-end=\"241\"><span style=\"font-family: arial, helvetica, sans-serif;\"><strong data-start=\"183\" data-end=\"241\">Overcoming Membrane Protein Expression Challenges\u2014Fast<\/strong><\/span><\/p>\n<p data-start=\"243\" data-end=\"573\"><span style=\"font-family: arial, helvetica, sans-serif;\">Membrane proteins remain among the most difficult yet valuable drug targets. This poster showcases how Sygnature Discovery uses a <strong data-start=\"373\" data-end=\"408\">rational, tool-enabled pipeline<\/strong> to express and purify these challenging targets, supporting applications from <strong data-start=\"486\" data-end=\"523\">cryo-EM and X-ray crystallography<\/strong> to <strong data-start=\"527\" data-end=\"572\">antibody discovery and biophysical assays<\/strong>.<\/span><\/p>\n<p data-start=\"575\" data-end=\"738\"><span style=\"font-family: arial, helvetica, sans-serif;\">In 2025, we delivered 100+ cryo-EM-ready samples using a proven workflow combining <strong data-start=\"658\" data-end=\"668\">Boltz2<\/strong>, <strong data-start=\"670\" data-end=\"682\">IMPROvER<\/strong>, <strong data-start=\"684\" data-end=\"702\">FSEC screening<\/strong>, and <strong data-start=\"708\" data-end=\"737\">thermostability profiling<\/strong>.<\/span><\/p>\n<p data-start=\"740\" data-end=\"848\"><span style=\"font-family: arial, helvetica, sans-serif;\">  <strong data-start=\"743\" data-end=\"771\">Download the free poster<\/strong> to learn how our integrated approach accelerates structural biology success.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2977,"template":"","category":[711,771,747,768,680,703,687],"class_list":["post-4209","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-biophysical-assays","category-cryo-em","category-gpcrs","category-membrane-proteins","category-protein-and-structure","category-protein-characterisation","category-target-classes"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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