{"id":4200,"date":"2025-09-26T21:49:59","date_gmt":"2025-09-26T21:49:59","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/accelerating-cns-drug-discovery-an-integrated-in-silico-and-in-vitro-approach-that-rapidly-contributes-to-compound-design-leading-to-increased-success-in-vivo\/"},"modified":"2026-01-22T13:29:32","modified_gmt":"2026-01-22T13:29:32","slug":"accelerating-cns-drug-discovery-an-integrated-in-silico-and-in-vitro-approach-that-rapidly-contributes-to-compound-design-leading-to-increased-success-in-vivo","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/accelerating-cns-drug-discovery-an-integrated-in-silico-and-in-vitro-approach-that-rapidly-contributes-to-compound-design-leading-to-increased-success-in-vivo\/","title":{"rendered":"Accelerating CNS Drug Discovery: An Integrated in silico and in vitro Approach that Rapidly Contributes to Compound Design Leading to Increased Success in vivo"},"content":{"rendered":"<p data-start=\"201\" data-end=\"236\"><span style=\"font-family: arial, helvetica, sans-serif;\"><strong data-start=\"201\" data-end=\"236\">Design Smarter CNS Drugs, Faster<\/strong><\/span><\/p>\n<p data-start=\"238\" data-end=\"429\"><span style=\"font-family: arial, helvetica, sans-serif;\">Discover how Sygnature Discovery combines <strong data-start=\"280\" data-end=\"305\"><em>in silico<\/em> predictions<\/strong> and <strong data-start=\"310\" data-end=\"327\"><em>in vitro<\/em> data<\/strong> to guide compound selection for <strong data-start=\"360\" data-end=\"392\">central nervous system (CNS)<\/strong> drug discovery, before going <em>in vivo<\/em>.<\/span><\/p>\n<p data-start=\"431\" data-end=\"629\"><span style=\"font-family: arial, helvetica, sans-serif;\">This integrated approach enables better predictions of <strong data-start=\"486\" data-end=\"505\">BBB penetration<\/strong>, <strong data-start=\"507\" data-end=\"532\">MDR1 efflux avoidance<\/strong>, and <strong data-start=\"538\" data-end=\"563\">human dose estimation<\/strong>, leading to more informed compound design and reduced animal use.<\/span><\/p>\n<p data-start=\"631\" data-end=\"752\"><span style=\"font-family: arial, helvetica, sans-serif;\">  <strong data-start=\"634\" data-end=\"662\">Download the free poster<\/strong> to see how this workflow helps accelerate CNS projects from idea to in vivo confirmation.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2965,"template":"","category":[683,728,753,721,719,688],"class_list":["post-4200","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-dmpk","category-modelling-and-simulation","category-neuroscience","category-permeability","category-physicochemical-profiling","category-therapeutic-areas"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - 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