{"id":4189,"date":"2025-09-21T02:00:14","date_gmt":"2025-09-21T02:00:14","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/shifting-the-spectrum-identification-of-novel-fragment-hits-for-the-vhl-elongin-b-c-complex-by-spectral-shift-and-spr\/"},"modified":"2026-01-22T13:35:39","modified_gmt":"2026-01-22T13:35:39","slug":"shifting-the-spectrum-identification-of-novel-fragment-hits-for-the-vhl-elongin-b-c-complex-by-spectral-shift-and-spr","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/shifting-the-spectrum-identification-of-novel-fragment-hits-for-the-vhl-elongin-b-c-complex-by-spectral-shift-and-spr\/","title":{"rendered":"Shifting the Spectrum: Identification of Novel Fragment Hits for the VHL-Elongin B\/C Complex by Spectral Shift and SPR"},"content":{"rendered":"

Novel Fragment Hits for VHL: Expanding the PROTAC Toolbox<\/strong><\/span><\/p>\n

Discover how Sygnature Discovery\u2019s curated fragment library<\/strong> and advanced screening platforms<\/strong> (Biacore 8K+, Dianthus) enable the identification of new VCB-binding fragments\u2014paving the way for more efficient and orally bioavailable PROTACs.<\/span><\/p>\n

Learn how we applied spectral shift and SPR screening<\/strong> to over 2,000 fragments to uncover untapped chemical space beyond classical VHL ligands.<\/span><\/p>\n

Download the free poster<\/strong> to explore this case study and accelerate your fragment-based drug discovery.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2950,"template":"","category":[706,681,755,686,743],"class_list":["post-4189","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-assay-development","category-bioscience","category-fbdd","category-modalities","category-tpd"],"acf":[],"yoast_head":"\nShifting the Spectrum: Identification of Novel Fragment Hits for the VHL-Elongin B\/C Complex by Spectral Shift and SPR - Sygnature<\/title>\n<meta name=\"description\" content=\"Download this free poster and learn how Sygnature Discovery identified novel VCB-binding fragments using fragment screening and SPR.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/shifting-the-spectrum-identification-of-novel-fragment-hits-for-the-vhl-elongin-b-c-complex-by-spectral-shift-and-spr\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Shifting the Spectrum: Identification of Novel Fragment Hits for the VHL-Elongin B\/C Complex by Spectral Shift and SPR - 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