{"id":4160,"date":"2025-05-21T07:00:23","date_gmt":"2025-05-21T07:00:23","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/high-throughput-molecular-glue-screening-platform\/"},"modified":"2026-01-22T14:06:51","modified_gmt":"2026-01-22T14:06:51","slug":"high-throughput-molecular-glue-screening-platform","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/high-throughput-molecular-glue-screening-platform\/","title":{"rendered":"High Throughput Molecular Glue Screening Platform"},"content":{"rendered":"<article class=\"text-token-text-primary w-full\" dir=\"auto\" data-testid=\"conversation-turn-140\" data-scroll-anchor=\"true\">\n<div class=\"text-base my-auto mx-auto py-5 [--thread-content-margin:--spacing(4)] @[37rem]:[--thread-content-margin:--spacing(6)] @[72rem]:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)\">\n<div class=\"[--thread-content-max-width:32rem] @[34rem]:[--thread-content-max-width:40rem] @[64rem]:[--thread-content-max-width:48rem] mx-auto flex max-w-(--thread-content-max-width) flex-1 text-base gap-4 md:gap-5 lg:gap-6 group\/turn-messages focus-visible:outline-hidden\" tabindex=\"-1\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"relative flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"2d99476d-4772-4a94-a421-491d0439bb31\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\n<div class=\"markdown prose dark:prose-invert w-full break-words light\">\n<p data-start=\"331\" data-end=\"857\">Targeted protein degradation (TPD) has emerged as a powerful therapeutic strategy\u2014but identifying viable molecular glues remains a complex challenge. In this poster, Sygnature Discovery presents an integrated high-throughput screening (HTS) platform designed to identify and validate molecular glue degraders with precision and efficiency tailored to your project. By combining cellular and biophysical screening with cheminformatics and expert assay development, our approach enables the rapid progression of hits with validated mechanisms of action.<\/p>\n<h2 data-start=\"859\" data-end=\"901\"><strong data-start=\"859\" data-end=\"901\">Our High-Throughput Screening Approach<\/strong><\/h2>\n<p data-start=\"903\" data-end=\"1073\">Molecular glue discovery often requires subtle differentiation between active and inactive compounds across diverse cellular contexts. Our platform supports this through:<\/p>\n<ul>\n<li data-start=\"1077\" data-end=\"1149\">HTRF-based screening in 1536-well format for robust hit identification<\/li>\n<li data-start=\"1152\" data-end=\"1219\">High content imaging and proteomics-informed validation workflows<\/li>\n<li data-start=\"1222\" data-end=\"1285\">Orthogonal and biophysical confirmation of target degradation<\/li>\n<li data-start=\"1288\" data-end=\"1351\">Cheminformatic triage to refine and prioritise validated hits<\/li>\n<\/ul>\n<h2 data-start=\"1353\" data-end=\"1399\"><strong data-start=\"1353\" data-end=\"1399\">Sygnature\u2019s Expertise in TPD and Screening<\/strong><\/h2>\n<p data-start=\"1401\" data-end=\"1515\">With deep experience across targeted degradation and phenotypic screening, Sygnature Discovery enables integrated projects to:<\/p>\n<ul>\n<li data-start=\"1519\" data-end=\"1584\">Develop robust, miniaturised cellular assays for glue screening<\/li>\n<li data-start=\"1587\" data-end=\"1652\">Perform multiplexed orthogonal validation to confirm mechanisms<\/li>\n<li data-start=\"1655\" data-end=\"1751\">Integrate chemical biology, medicinal chemistry, and ADME expertise for downstream hit progression<\/li>\n<\/ul>\n<p data-start=\"1753\" data-end=\"1901\"><strong data-start=\"1753\" data-end=\"1781\">Download the full poster to explore how Sygnature Discovery\u2019s integrated compound high-throughput screening platform is advancing <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/integrated-drug-discovery\/targeted-protein-degradation\/molecular-glues\/\" target=\"_blank\" rel=\"noopener\">molecular glue<\/a> drug discovery.<\/strong><\/p>\n<p data-start=\"1903\" data-end=\"2105\" data-is-last-node=\"\" data-is-only-node=\"\">At Sygnature Discovery, our screening teams provide scalable solutions to de-risk and accelerate your <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/integrated-drug-discovery\/targeted-protein-degradation\/\">targeted protein degradation<\/a> programmes. Speak to the team today to learn how we can support your glue discovery efforts.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"absolute\">\n<div class=\"flex items-center justify-center\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<div class=\"pointer-events-none h-px w-px\" aria-hidden=\"true\" data-edge=\"true\"><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2908,"template":"","category":[710,711,681,709,708,690,686,743],"class_list":["post-4160","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-biochemical-assays","category-biophysical-assays","category-bioscience","category-cell-based-assays","category-high-throughput-screening","category-hit-identification","category-modalities","category-tpd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>High Throughput Molecular Glue 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