{"id":4148,"date":"2025-04-30T13:00:14","date_gmt":"2025-04-30T13:00:14","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/pd1-inhibition-ratiotherapy-parp-colorectal-model\/"},"modified":"2026-01-22T14:08:07","modified_gmt":"2026-01-22T14:08:07","slug":"pd1-inhibition-ratiotherapy-parp-colorectal-model","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/pd1-inhibition-ratiotherapy-parp-colorectal-model\/","title":{"rendered":"Characterization of the tumor immune infiltrate in a colorectal syngeneic model dose with anti-PD-1 in combination with radiotherapy or PARP inhibitor"},"content":{"rendered":"<p>Sygnature Discovery presents new data evaluating how PD1 inhibition, alone and in combination with radiotherapy or PARP inhibition, influences immune cell infiltration and cytokine responses in the MC38 colorectal syngeneic colorectal model. The findings support the use of these models to investigate combination strategies and tumour immune modulation in preclinical immuno-oncology.<\/p>\n<p>Study Highlights:<\/p>\n<ul>\n<li>Enhanced efficacy with PD1 inhibition and radiotherapy<\/li>\n<li>Distinct immune profiles with PD1 based combinations<\/li>\n<li>Niraparib modulates infiltration, but limits efficacy<\/li>\n<li>Cytokine analysis support immune modulation<\/li>\n<\/ul>\n<p>Supporting PD1 Inhibition Strategies in Preclinical IO<\/p>\n<p>These findings provide insight into how PD1 inhibition interacts with radiotherapy and PARP inhibition at the tumour microenvironment level. The MC38 model demonstrates utility in assessing immune checkpoint combinations, helping to shape rational IO drug development strategies.<\/p>\n<p>Explore our Immuno-Oncology Expertise<\/p>\n<p>Sygnature Discovery supports PD1 inhibition and combination strategies through our integrated <a href=\"https:\/\/www.sygnaturediscovery.com\/therapeutic-areas\/oncology-and-immuno-oncology\/\">preclinical immuno-oncology<\/a> offering. Our capabilities span <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/in-vivo-pharmacology-and-in-vivo-testing\/\">in vivo syngeneic models<\/a>, immune phenotyping by flow cytometry and cytokine profiling to support mechanism-of-action and efficacy studies.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2889,"template":"","category":[685,751,738],"class_list":["post-4148","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-in-vivo-pharmacology","category-oncology","category-oncology-models"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PD1 Inhibitor Modulates Immune Infiltrate in a MC38 Model<\/title>\n<meta name=\"description\" content=\"PD-1 inhibition enhances immune activation in the MC38 model when combined with radiotherapy. Explore our tumour immune profiling services.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/pd1-inhibition-ratiotherapy-parp-colorectal-model\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PD1 Inhibitor Modulates Immune Infiltrate in a MC38 Model\" \/>\n<meta property=\"og:description\" content=\"PD-1 inhibition enhances immune activation in the MC38 model when combined with radiotherapy. 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