{"id":4142,"date":"2025-01-23T11:54:40","date_gmt":"2025-01-23T11:54:40","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/reducing-dcm-use\/"},"modified":"2026-01-22T14:23:37","modified_gmt":"2026-01-22T14:23:37","slug":"reducing-dcm-use","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/reducing-dcm-use\/","title":{"rendered":"Reducing DCM Use"},"content":{"rendered":"<p>As the demand for greener, more sustainable drug discovery grows, minimising the use of environmentally harmful solvents such as dichloromethane (DCM) is a key focus for synthetic chemistry teams. In this poster, Sygnature Discovery shares its internal sustainability initiative to reduce DCM use during reaction work-up &#8211; without compromising scientific integrity or product quality.<\/p>\n<h3>Why Reduce DCM Use?<\/h3>\n<p>Dichloromethane (DCM) is a popular solvent choice in synthetic chemistry, particularly for chromatography. It has high eluting power for polar compounds, volatility and availability have made it a staple in many labs.<\/p>\n<p>However, DCM poses significant health and environmental risks:<\/p>\n<ul>\n<li>It has acute and chronic toxicity in humans, including respiratory, cardiovascular and central nervous system effects<\/li>\n<li>DCM is a suspected carcinogen and genotoxin <sup>1<\/sup><\/li>\n<li>Environmentally, DCM is persistent ((t<sub>1\/2<\/sub> = 18 months in water) and contributes to ozone depletion and other ecological harm\u00a0<sup>1<\/sup><\/li>\n<\/ul>\n<h3>Sygnature&rsquo;s Sustainable Chemistry Approach<\/h3>\n<p>In response, Sygnature Discovery has taken pre-emptive action to reduce our reliance on DCM as part of our company-wide commitment to sustainability.<\/p>\n<p>Over the last five years, we&rsquo;ve reduced our DCM use by over 50% &#8211; amounting to 19 tonnes of solvent &#8211; while maintaining scientific productivity and delivering on-spec products for our clients.<\/p>\n<p>[1] <a href=\"https:\/\/www.govinfo.gov\/content\/pkg\/FR-2024-05-08\/pdf\/2024-09606.pdf\">https:\/\/www.govinfo.gov\/content\/pkg\/FR-2024-05-08\/pdf\/2024-09606.pdf<\/a><\/p>\n<h3>Join Us in Sustainable Drug Discovery<\/h3>\n<p>We believe that greater science and environmental responsibility go hand in hand. If you&rsquo;re looking for a partner who can deliver innovative synthetic chemistry while supporting your sustainability goals<a href=\"https:\/\/www.sygnaturediscovery.com\/contact\/\"> contact us today.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2880,"template":"","category":[682,714],"class_list":["post-4142","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-chemistry","category-synthetic-chemistry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Reducing DCM Use in Reaction Work-Up<\/title>\n<meta name=\"description\" content=\"Explore Sygnature Discovery&#039;s sustainability chemistry poster on reducing DCM use in reaction work-up without compromising yield or purity.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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