{"id":4140,"date":"2024-11-26T11:02:12","date_gmt":"2024-11-26T11:02:12","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/comparison-of-%c2%b1mdma-fluoxetine-and-dexfenfluramine-to-inhibit-uptake-and-or-stimulate-release-of-3h5-ht-in-rat-frontal-cortical-synaptosomes\/"},"modified":"2026-01-22T14:30:30","modified_gmt":"2026-01-22T14:30:30","slug":"comparison-of-%c2%b1mdma-fluoxetine-and-dexfenfluramine-to-inhibit-uptake-and-or-stimulate-release-of-3h5-ht-in-rat-frontal-cortical-synaptosomes","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/comparison-of-%c2%b1mdma-fluoxetine-and-dexfenfluramine-to-inhibit-uptake-and-or-stimulate-release-of-3h5-ht-in-rat-frontal-cortical-synaptosomes\/","title":{"rendered":"Serotonin Uptake and Release: Comparing (\u00b1)MDMA, Fluoxetine, and Dexfenfluramine"},"content":{"rendered":"

Understanding how compounds modulate neurotransmitter transport is critical in the development of psychiatric medications. This study investigates the functional effects of three compounds – (\u00b1)MDMA, fluoxetine, and dexfenfluramine\u2014 on the serotonin transporter (SERT), using [3<\/sup>H]5-HT uptake and release assay in isolated rat frontal cortical synaptosomes.<\/p>\n

Functional Assays for Monoamine Transporter Pharmacology<\/h3>\n

Uptake and release assays are functional in vitro<\/em> techniques used to investigate the ability of compounds to either inhibit reuptake or induce release of neurotransmitters via monoamine transporters.<\/p>\n

The serotonin transporter (SERT) plays a major role in regulating serotonergic neurotransmission within the central nervous system (CNS) and is a key target in the treatment of psychiatric disorders such as anxiety, PTSD and depression.<\/p>\n

The aim of this study was to assess how (\u00b1)MDMA, dexfenfluramine and fluoxetine affect the uptake and release of [3<\/sup>H]5-HT using rat frontal cortical synaptosomes – providing pharmacological insights into their mechanism of action.<\/p>\n

Expertise in Neurotransmitter Pharmacology<\/p>\n

At Sygnature Discovery, our in vitro<\/em> biology<\/a> and neuroscience<\/a> teams specialize in transporter assays, functional screening and mechanistic profiling to support early-stage CNS drug discovery.<\/p>\n

Speak to our neuroscience experts<\/a> to discuss your monoamine transporter project.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2877,"template":"","category":[681,753,688,748],"class_list":["post-4140","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-neuroscience","category-therapeutic-areas","category-transporters"],"acf":[],"yoast_head":"\nUptake and Release of 5-HT: MDMA vs Fluoxetine<\/title>\n<meta name=\"description\" content=\"Sygnature\u2019s poster comparing MDMA, fluoxetine and dexfenfluramine in serotonin uptake and release assays in rat cortical synaptosomes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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