{"id":4138,"date":"2024-11-26T11:00:22","date_gmt":"2024-11-26T11:00:22","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/binding-affinities-of-a-range-of-psychedelics-for-5-ht1a-5-ht2a-and-5-ht2c-receptors-in-rodent-brain\/"},"modified":"2026-01-22T14:34:42","modified_gmt":"2026-01-22T14:34:42","slug":"binding-affinities-of-a-range-of-psychedelics-for-5-ht1a-5-ht2a-and-5-ht2c-receptors-in-rodent-brain","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/binding-affinities-of-a-range-of-psychedelics-for-5-ht1a-5-ht2a-and-5-ht2c-receptors-in-rodent-brain\/","title":{"rendered":"Binding affinities of a range of psychedelics for 5-HT1A, 5-HT2A and 5-HT2C receptors in rodent brain"},"content":{"rendered":"

Psychedelic compounds are at the forefront of neuroscience drug discovery, offering new hope for treating a range of CNS disorder. But how do these molecules bind to serotonin (5-HT) receptors?<\/p>\n

In this poster, Sygnature Discovery presents new data on the binding affinities of psychedelic and non-psychedelic compounds across 5-HT1A, 5-HT2A, and 5-HT2C receptors using radioligand binding assays in rodent brain tissue.<\/p>\n

Receptor Binding: Validated Psychedelic Assays<\/h3>\n

Receptor binding assays utilize ligands labelled with radioisotopes such as tritium ([3<\/sup>H]) to determine the pharmacology and non-radiolabelled compounds at a receptor of interest. Competition assays determine the affinity of a ligand for a receptor by displacing a known concentration of a radioligand.<\/p>\n

At Sygnature Discovery, we have recently validated binding assays to compare the receptor binding profiles of a range of psychedelic and non-psychedelic compounds at 5-HT1A, 5-HT2A, and 5-HT2C receptors using [3<\/sup>H]8-OH-DPAT, [3<\/sup>H]Cimbi-36 and [3<\/sup>H]Mesulergine, respectively, in rodent brain.<\/p>\n

Want to explore how we can support your GPCR or CNS drug discovery program?<\/p>\n

Get in touch with our team<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2874,"template":"","category":[681,747,753,688],"class_list":["post-4138","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-gpcrs","category-neuroscience","category-therapeutic-areas"],"acf":[],"yoast_head":"\nPsychedelic Binding Affinities at 5-HT Receptors<\/title>\n<meta name=\"description\" content=\"Explore binding affinities of psychedelic and non-psychedelic compounds at 5-HT1A, 5-HT2A and 5-HT2C receptors using radioligand assays.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/binding-affinities-of-a-range-of-psychedelics-for-5-ht1a-5-ht2a-and-5-ht2c-receptors-in-rodent-brain\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta 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