{"id":4130,"date":"2024-09-27T09:01:45","date_gmt":"2024-09-27T09:01:45","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/modelling-nicotine-relapse-validating-the-rat-intravenous-self-administration-model-for-efficacy-testing-novel-treatments-for-nicotine-addiction\/"},"modified":"2026-01-22T14:58:16","modified_gmt":"2026-01-22T14:58:16","slug":"modelling-nicotine-relapse-validating-the-rat-intravenous-self-administration-model-for-efficacy-testing-novel-treatments-for-nicotine-addiction","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/modelling-nicotine-relapse-validating-the-rat-intravenous-self-administration-model-for-efficacy-testing-novel-treatments-for-nicotine-addiction\/","title":{"rendered":"Modelling nicotine relapse: validating the rat intravenous self-administration model for efficacy testing novel treatments for nicotine addiction"},"content":{"rendered":"

Sygnature has been performing preclinical models of drug abuse liability for over 15 years. Here we modify the well-established rat intravenous self-administration model to investigate treatments for substance use disorders, namely nicotine addiction. Rats readily self-administer nicotine and associate positive reinforcement with environmental cues.\u00a0 Varenicline, a nicotinic acetylcholine receptor agonist commonly prescribed for nicotine cessation, significantly attenuates drug seeking behaviours in rats exposed to nicotine and non-reinforced cues. The model is a useful tool in preclinical efficacy testing of novel therapies for nicotine cessation.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2862,"template":"","category":[735,685,753],"class_list":["post-4130","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-cns-pain-models","category-in-vivo-pharmacology","category-neuroscience"],"acf":[],"yoast_head":"\nModelling nicotine relapse: validating the rat intravenous self-administration model for efficacy testing novel treatments for nicotine addiction - Sygnature<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/modelling-nicotine-relapse-validating-the-rat-intravenous-self-administration-model-for-efficacy-testing-novel-treatments-for-nicotine-addiction\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Modelling nicotine relapse: validating the rat intravenous self-administration model for efficacy testing novel treatments for nicotine addiction - 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