FIDA (Flow-Induced Dispersion Analysis) allows rapid measurement of protein size in solution and can be done with or without a fluorescent label. We can use this information to study both functional and structural properties, evaluating protein stability, activity, and ligand binding \u2013 and this all can be done in solution using a single instrument. At Sygnature Discovery, we have used FIDA for measuring protein stability, oligomeric state and aggregation. We have also measured protein-ligand interactions, protein-protein\/nucleic acid interactions, unfolding, liquid-liquid phase separation, and fluorophore environment changes.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2847,"template":"","category":[768,680,703],"class_list":["post-4120","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-membrane-proteins","category-protein-and-structure","category-protein-characterisation"],"acf":[],"yoast_head":"\n