{"id":4076,"date":"2024-08-14T13:27:29","date_gmt":"2024-08-14T13:27:29","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/efficient-metal-free-synthesis-of-23-disubstituted-pyridopyrimidones-via-ketenimine-intermediates\/"},"modified":"2026-01-22T15:24:28","modified_gmt":"2026-01-22T15:24:28","slug":"efficient-metal-free-synthesis-of-23-disubstituted-pyridopyrimidones-via-ketenimine-intermediates","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/efficient-metal-free-synthesis-of-23-disubstituted-pyridopyrimidones-via-ketenimine-intermediates\/","title":{"rendered":"Efficient &#038; Metal-Free Synthesis of 2,3-Disubstituted Pyridopyrimidones via Ketenimine Intermediates"},"content":{"rendered":"<p>A highly efficient synthesis has been developed for the direct access of 2,3-disubstituted 4<em>H<\/em>-pyrido[1,2-<em>a<\/em>] pyrimidin-4-ones from <em>N<\/em>-pyridoketenimine precursors.<\/p>\n<p>The ketenimine intermediates are demonstrated to react efficiently with <em>N<\/em>-, <em>S<\/em>-, <em>O<\/em>&#8211; and <em>C<\/em>-nucleophiles, and provide the corresponding disubstituted pyridopyrimidinone products in good yields. This one-pot method is operationally simple and avoids the use of transition metals, enabling rapid assembly of this type of structural motif for SAR studies as well as late-stage process development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This poster details the efficient synthesis of 2,3-disubstituted 4H-pyrido[1,2-a]pyrimidin-4-ones via N-pyridoketenimines reacting with various nucleophiles. Download for more information on this metal-free, one-pot method ideal for SAR studies and process development.<\/p>\n","protected":false},"featured_media":2780,"template":"","category":[682],"class_list":["post-4076","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-chemistry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Efficient &amp; Metal-Free Synthesis of 2,3-Disubstituted Pyridopyrimidones via Ketenimine Intermediates - Sygnature<\/title>\n<meta name=\"description\" content=\"This poster details the efficient synthesis of 2,3-disubstituted 4H-pyrido[1,2-a]pyrimidin-4-ones. 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