{"id":4067,"date":"2024-07-12T13:42:24","date_gmt":"2024-07-12T13:42:24","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/profiling-of-lps-induced-acute-systemic-inflammation-in-the-mouse\/"},"modified":"2026-01-22T15:33:11","modified_gmt":"2026-01-22T15:33:11","slug":"profiling-of-lps-induced-acute-systemic-inflammation-in-the-mouse","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/profiling-of-lps-induced-acute-systemic-inflammation-in-the-mouse\/","title":{"rendered":"Profiling of LPS-Induced Acute Systemic Inflammation in the Mouse"},"content":{"rendered":"

Inflammation has recently become implicated in the development and progression of disease in many areas such as oncology, metabolic disorders as well as neurodegeneration. Inflammatory diseases have a high socioeconomic burden producing significant morbidity, (pain, impaired function, diminished quality of life) as well as economic impacts (absenteeism, decreased productivity, healthcare costs), plus mortality across the globe.<\/span><\/span><\/p>\n

In this poster we demonstrate the reproducibility of our <\/span>Lipopolysachharide<\/span> (LPS) mouse model, both in terms of the initial cytokine response as well as the mitigation of that response using gold standard compounds, Dexamethasone and TAK-242. The reproducibility of our model enables direct comparison of the efficacy of novel treatments within and across chemical series. The model emulates many of the pro-inflammatory biomarkers present in humans (IL-6 data only shown), both in the circulatory system and tissues. The flexibility of readout from a single intraperitoneal dose provides a robust platform to investigate therapeutic interventions targeting excessive inflammation in both the periphery and a variety of tissues.<\/span><\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2767,"template":"","category":[752,685,727,737,688],"class_list":["post-4067","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-ii","category-in-vivo-pharmacology","category-in-vivo-pk-pd","category-inflammation-immunology-models","category-therapeutic-areas"],"acf":[],"yoast_head":"\nProfiling of LPS-Induced Acute Systemic Inflammation in Mouse<\/title>\n<meta name=\"description\" content=\"The reproducibility of our (LPS) mouse model, both in terms of the initial cytokine response as well as the mitigation of that response\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/profiling-of-lps-induced-acute-systemic-inflammation-in-the-mouse\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Profiling of LPS-Induced Acute Systemic Inflammation in Mouse\" \/>\n<meta property=\"og:description\" content=\"The reproducibility of our (LPS) mouse model, both in terms of the initial cytokine response as well as the mitigation of that response\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/profiling-of-lps-induced-acute-systemic-inflammation-in-the-mouse\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-22T15:33:11+00:00\" \/>\n<meta property=\"og:image\" 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