{"id":4016,"date":"2023-11-02T11:41:07","date_gmt":"2023-11-02T11:41:07","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/"},"modified":"2026-01-22T16:51:54","modified_gmt":"2026-01-22T16:51:54","slug":"preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/","title":{"rendered":"Preventative effects of dexamethasone in lipopolysaccharide-induced neuroinflammation"},"content":{"rendered":"

The study investigates the preventative effects of dexamethasone on lipopolysaccharide (LPS)-induced neuroinflammation.<\/p>\n

Neuroinflammation is associated with neurodegenerative disorders and plays a role in disease progression. The researchers examined the gene expression of proinflammatory cytokines in the brains of mice after LPS administration, with and without pre-administration of dexamethasone. They found that LPS significantly increased the expression of IL1\u03b2, IL-6, and TNF-\u03b1, while dexamethasone dose-dependently reduced the expression of IL1\u03b2 and TNF-\u03b1. However, dexamethasone had no significant effect on IL-6 expression.<\/p>\n

The study suggests that LPS-induced neuroinflammation can be effectively inhibited by dexamethasone and that this model can be used to test the efficacy of anti-inflammatory agents.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2691,"template":"","category":[685,737,753],"class_list":["post-4016","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-in-vivo-pharmacology","category-inflammation-immunology-models","category-neuroscience"],"acf":[],"yoast_head":"\nPreventative Effects of Dexamethasone in Neuroinflammation<\/title>\n<meta name=\"description\" content=\"This in vivo LPS model represents a useful approach for testing the efficacy of novel anti-inflammatory agents against neuroinflammation\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preventative Effects of Dexamethasone in Neuroinflammation\" \/>\n<meta property=\"og:description\" content=\"This in vivo LPS model represents a useful approach for testing the efficacy of novel anti-inflammatory agents against neuroinflammation\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-22T16:51:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Preventative-effects-of-dexamethasone-in-LPS-induced-neuroinflammation-e1744810068144.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"888\" \/>\n\t<meta property=\"og:image:height\" content=\"628\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\\\/\",\"name\":\"Preventative Effects of Dexamethasone in Neuroinflammation\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Preventative-effects-of-dexamethasone-in-LPS-induced-neuroinflammation-e1744810068144.jpg\",\"datePublished\":\"2023-11-02T11:41:07+00:00\",\"dateModified\":\"2026-01-22T16:51:54+00:00\",\"description\":\"This in vivo LPS model represents a useful approach for testing the efficacy of novel anti-inflammatory agents against neuroinflammation\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Preventative-effects-of-dexamethasone-in-LPS-induced-neuroinflammation-e1744810068144.jpg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Preventative-effects-of-dexamethasone-in-LPS-induced-neuroinflammation-e1744810068144.jpg\",\"width\":888,\"height\":628},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/page-daccueil\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preventative effects of dexamethasone in lipopolysaccharide-induced neuroinflammation\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"name\":\"Sygnature Discovery\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\"},\"alternateName\":\"Sygnature\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\",\"name\":\"Sygnature Discovery\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Sygnature Discovery\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Preventative Effects of Dexamethasone in Neuroinflammation","description":"This in vivo LPS model represents a useful approach for testing the efficacy of novel anti-inflammatory agents against neuroinflammation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/","og_locale":"fr_CA","og_type":"article","og_title":"Preventative Effects of Dexamethasone in Neuroinflammation","og_description":"This in vivo LPS model represents a useful approach for testing the efficacy of novel anti-inflammatory agents against neuroinflammation","og_url":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/","og_site_name":"Sygnature","article_modified_time":"2026-01-22T16:51:54+00:00","og_image":[{"width":888,"height":628,"url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Preventative-effects-of-dexamethasone-in-LPS-induced-neuroinflammation-e1744810068144.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimation du temps de lecture":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/","url":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/","name":"Preventative Effects of Dexamethasone in Neuroinflammation","isPartOf":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/#primaryimage"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Preventative-effects-of-dexamethasone-in-LPS-induced-neuroinflammation-e1744810068144.jpg","datePublished":"2023-11-02T11:41:07+00:00","dateModified":"2026-01-22T16:51:54+00:00","description":"This in vivo LPS model represents a useful approach for testing the efficacy of novel anti-inflammatory agents against neuroinflammation","breadcrumb":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/#primaryimage","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Preventative-effects-of-dexamethasone-in-LPS-induced-neuroinflammation-e1744810068144.jpg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Preventative-effects-of-dexamethasone-in-LPS-induced-neuroinflammation-e1744810068144.jpg","width":888,"height":628},{"@type":"BreadcrumbList","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/preventative-effects-of-dexamethasone-in-lipopolysaccharide-induced-neuroinflammation\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sygnaturediscovery.com\/fr\/page-daccueil\/"},{"@type":"ListItem","position":2,"name":"Preventative effects of dexamethasone in lipopolysaccharide-induced neuroinflammation"}]},{"@type":"WebSite","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","name":"Sygnature Discovery","description":"","publisher":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization"},"alternateName":"Sygnature","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sygnaturediscovery.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"},{"@type":"Organization","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization","name":"Sygnature Discovery","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","width":1,"height":1,"caption":"Sygnature Discovery"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/poster\/4016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/poster"}],"about":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/types\/poster"}],"version-history":[{"count":0,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/poster\/4016\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media\/2691"}],"wp:attachment":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media?parent=4016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/category?post=4016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}