{"id":3998,"date":"2023-09-27T13:53:10","date_gmt":"2023-09-27T13:53:10","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/assessing-the-effects-of-four-clinically-used-analgesics-in-two-mechanistic-stimuli-evoked-acute-pain-models-in-mice-demonstrates-good-predictive-nature-of-the-phase-2-of-formalin-pain-model\/"},"modified":"2026-01-22T17:11:10","modified_gmt":"2026-01-22T17:11:10","slug":"assessing-the-effects-of-four-clinically-used-analgesics-in-two-mechanistic-stimuli-evoked-acute-pain-models-in-mice-demonstrates-good-predictive-nature-of-the-phase-2-of-formalin-pain-model","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/assessing-the-effects-of-four-clinically-used-analgesics-in-two-mechanistic-stimuli-evoked-acute-pain-models-in-mice-demonstrates-good-predictive-nature-of-the-phase-2-of-formalin-pain-model\/","title":{"rendered":"Assessing the effects of four clinically used analgesics in two mechanistic stimuli-evoked acute pain models in mice demonstrates good predictive nature of the phase 2 of formalin pain model."},"content":{"rendered":"<p>Due to very high clinical attrition rates, the predictive value of the preclinical pain models has been questioned in recent years. Even though several disease-related chronic pain models are currently available, the roles of stimuli-evoked acute pain models are also important due to their quick screening capabilities and their mechanistic relevance to the process of pain transmission. In this context, we have examined the back-translational effects of four clinically used analgesics in two common acute <a href=\"https:\/\/nuchemsciences.com\/#\">pain models<\/a> in mice: the heat-evoked tail-immersion model and the chemically-evoked formalin model.<\/p>\n<p>The effects of these drugs mainly in the second phase of the formalin model is noteworthy since this phase involves a neuronal process called central sensitization, which is known to be implicated in the generation of chronic pain. Hence, we suggest that the second phase of the formalin model could be used as a very cost-effective and quick screening model in predicting the analgesic effects of novel pain therapeutic targets in preclinical drug discovery.<\/p>\n<p>&nbsp;<\/p>\n<p>NuChem Sciences and Sygnature Discovery are now collaborating closely. To highlight our combined expertise and collaborative efforts, NuChem&rsquo;s poster has been shared on Sygnature Discovery&rsquo;s website and we are proud to be able to count on their expertise in pharmacology, especially with pain models, to offer our customers even more services. This serves as a testament to our <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/integrated-drug-discovery\/\">integrated<\/a> approach and the synergy between our companies<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Explore the significance of acute pain models in predicting the efficacy of novel pain therapeutics and uncover their role in preclinical drug discovery. Download our poster to gain valuable insights into chronic pain prediction through cost-effective and quick screening models.<\/p>\n","protected":false},"featured_media":2664,"template":"","category":[735,685,753,688],"class_list":["post-3998","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-cns-pain-models","category-in-vivo-pharmacology","category-neuroscience","category-therapeutic-areas"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Analgesics in Stimuli-Evoked Acute Pain Models<\/title>\n<meta name=\"description\" content=\"Four clinically used analgesics tested in mouse tail-immersion and formalin models, and why formalin phase 2 suits rapid analgesic screening. Learn more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/assessing-the-effects-of-four-clinically-used-analgesics-in-two-mechanistic-stimuli-evoked-acute-pain-models-in-mice-demonstrates-good-predictive-nature-of-the-phase-2-of-formalin-pain-model\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analgesics in Stimuli-Evoked Acute Pain Models\" \/>\n<meta property=\"og:description\" content=\"Four clinically used analgesics tested in mouse tail-immersion and formalin models, and why formalin phase 2 suits rapid analgesic screening. 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