{"id":3990,"date":"2023-09-27T10:45:47","date_gmt":"2023-09-27T10:45:47","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/building-a-neuroscience-drug-discovery-platform\/"},"modified":"2026-01-22T17:13:52","modified_gmt":"2026-01-22T17:13:52","slug":"building-a-neuroscience-drug-discovery-platform","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/building-a-neuroscience-drug-discovery-platform\/","title":{"rendered":"Building a Neuroscience Drug Discovery Platform"},"content":{"rendered":"

Neuroscience<\/a> encompasses a wide range of diseases, from neurodevelopmental to neurological and psychiatric conditions. To establish a neuroscience drug discovery platform (NDDP), we must make careful choices. At Sygnature Discovery, we have prioritized four key pillars for our NDDP: Disease-agnostic mechanisms, Neuroinflammation, Biomarkers, and Neuroplasticity.<\/p>\n

We complement these four pillars with (i) an emphasis on humanizing the drug discovery process wherever possible (e.g., utilizing iPSCs, PBMCs, etc.) and (ii) an extensive in-vivo pharmacology capability that focuses on assessing behavioural and ex-vivo efficacy and safety, including the use of transgenic animal models. Our neuroscience drug discovery platform adheres to industry principles, including achieving target exposure multiples, providing evidence of on-target binding, and considering PK\/PD. It is driven by a multidisciplinary team of over 200 scientists who specialize in Bioscience, DMPK, and in-vivo Pharmacology.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2652,"template":"","category":[681,709,735,683,740,685,727,753,688],"class_list":["post-3990","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-cell-based-assays","category-cns-pain-models","category-dmpk","category-ex-vivo-tissue-analysis","category-in-vivo-pharmacology","category-in-vivo-pk-pd","category-neuroscience","category-therapeutic-areas"],"acf":[],"yoast_head":"\nBuilding a Neuroscience Drug Discovery Platform - Sygnature<\/title>\n<meta name=\"description\" content=\"Explore Sygnature Discovery's neuroscience drug discovery platform, built on four pillars. 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