{"id":3976,"date":"2023-06-22T13:30:06","date_gmt":"2023-06-22T13:30:06","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/microglia-mdmi-screening-platform-for-identifying-novel-anti-neuroinflammatory-drugs\/"},"modified":"2025-12-12T11:37:08","modified_gmt":"2025-12-12T11:37:08","slug":"microglia-mdmi-screening-platform-for-identifying-novel-anti-neuroinflammatory-drugs","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/microglia-mdmi-screening-platform-for-identifying-novel-anti-neuroinflammatory-drugs\/","title":{"rendered":"Generation and validation of human monocyte-derived microglia (MDMi); a Sygnature Discovery screening platform for identifying novel anti-neuroinflammatory drugs"},"content":{"rendered":"<p class=\"contentpasted0\"><span style=\"color: #006aab;\">At Sygnature Discovery, we have recently validated the methodology to generate MDMi, an <span class=\"contentpasted01\"><i>in vitro <\/i><\/span>human cell model to allow the study of anti-neuroinflammatory drugs.<\/span><\/p>\n<p class=\"contentpasted0\"><span style=\"color: black;\">\u00a0<\/span><\/p>\n<p class=\"contentpasted0\"><span style=\"color: black;\">To overcome some of the limitations of primary microglia (limited cell number and restricted life-span <span class=\"contentpasted01\"><i>in vitro<\/i><\/span>), Sygnature Discovery has validated the generation of MDMi from human monocytes. MDMi shows consistent phenotypic characteristics with primary microglia, as well as expected functionality with P2X7 receptor-mediated calcium signalling and phagocytosis. MDMi shows potential as a microglia model for identifying and characterising novel anti-neuroinflammatory drugs and assisting in the <span class=\"contentpasted01\"><i>in vitro <\/i><\/span>to <span class=\"contentpasted01\"><i>in vivo <\/i><\/span>translation.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2631,"template":"","category":[1],"class_list":["post-3976","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Microglia screening platform<\/title>\n<meta name=\"description\" content=\"This poster showcases Sygnature Discovery&#039;s work on developing and validating an in vitro assay for studying microglia function.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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