{"id":3970,"date":"2020-06-25T10:01:42","date_gmt":"2020-06-25T10:01:42","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\/"},"modified":"2025-12-12T11:37:03","modified_gmt":"2025-12-12T11:37:03","slug":"developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\/","title":{"rendered":"Developing sensitive arrays to facilitate hit identification of RNA modifying enzymes"},"content":{"rendered":"

To facilitate and accelerate drug discovery efforts in this area, we have developed several sensitive and robust assays suitable for identifying and assessing chemical matter against the RNA modifying enzymes FTO and METTL3\/METTL14<\/p>\n

\"\"

Schematic representing the role of FTO and METTL3\/METTL14 in the regulation of the transcriptome via removal of the m6A modification from RNA.<\/p><\/div>\n

An MST assay was developed, validated and used to screen 100 compounds from the LOPAC for novel human FTO small molecule binders.<\/p>\n

Our proof of concept study describes the development of several robust and sensitive assays for hit identification and
\nfurther characterisation of inhibitors of key RNA modifying enzymes and offers a platform for the discovery and
\ndevelopment of novel therapeutics in this emerging area of research.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2623,"template":"","category":[1],"class_list":["post-3970","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nAdvancing Hit Identification of RNA Modifying Enzymes<\/title>\n<meta name=\"description\" content=\"Robust, sensitive assays for hit identification against FTO and METTL3\/METTL14, including an MST screen of 100 LOPAC compounds for FTO binders. Learn more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Advancing Hit Identification of RNA Modifying Enzymes\" \/>\n<meta property=\"og:description\" content=\"Robust, sensitive assays for hit identification against FTO and METTL3\/METTL14, including an MST screen of 100 LOPAC compounds for FTO binders. 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