{"id":3970,"date":"2020-06-25T10:01:42","date_gmt":"2020-06-25T10:01:42","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\/"},"modified":"2025-12-12T11:37:03","modified_gmt":"2025-12-12T11:37:03","slug":"developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\/","title":{"rendered":"Developing sensitive arrays to facilitate hit identification of RNA modifying enzymes"},"content":{"rendered":"<p>To facilitate and accelerate drug discovery efforts in this area, we have developed several sensitive and robust assays suitable for identifying and assessing chemical matter against the RNA modifying enzymes FTO and METTL3\/METTL14<\/p>\n<div id=\"attachment_8901\" style=\"width: 514px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-8901\" class=\"wp-image-8901\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/poster-aacr-chris-t-intro.jpg\" alt=\"\" width=\"504\" height=\"196\"><p id=\"caption-attachment-8901\" class=\"wp-caption-text\">Schematic representing the role of FTO and METTL3\/METTL14 in the regulation of the transcriptome via removal of the m6A modification from RNA.<\/p><\/div>\n<p>An MST assay was developed, validated and used to screen 100 compounds from the LOPAC for novel human FTO small molecule binders.<\/p>\n<p>Our proof of concept study describes the development of several robust and sensitive assays for hit identification and<br>\nfurther characterisation of inhibitors of key RNA modifying enzymes and offers a platform for the discovery and<br>\ndevelopment of novel therapeutics in this emerging area of research.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2623,"template":"","category":[1],"class_list":["post-3970","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Advancing Hit Identification of RNA Modifying Enzymes<\/title>\n<meta name=\"description\" content=\"Discover Sensitive Assays for RNA Modifying Enzymes FTO and METTL3\/METTL14. Explore our MST assay screening 100 compounds for FTO small molecule binders.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Advancing Hit Identification of RNA Modifying Enzymes\" \/>\n<meta property=\"og:description\" content=\"Discover Sensitive Assays for RNA Modifying Enzymes FTO and METTL3\/METTL14. Explore our MST assay screening 100 compounds for FTO small molecule binders.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-12T11:37:03+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Hit-ID-of-RNA-modif-enzyme.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1076\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\\\/\",\"name\":\"Advancing Hit Identification of RNA Modifying Enzymes\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/developing-sensitive-arrays-to-facilitate-hit-identification-of-rna-modifying-enzymes\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Hit-ID-of-RNA-modif-enzyme.jpg\",\"datePublished\":\"2020-06-25T10:01:42+00:00\",\"dateModified\":\"2025-12-12T11:37:03+00:00\",\"description\":\"Discover Sensitive Assays for RNA Modifying Enzymes FTO and METTL3\\\/METTL14. 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