{"id":3952,"date":"2019-10-09T09:33:15","date_gmt":"2019-10-09T09:33:15","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/is-ticlopidine-a-suitable-control-compound-for-assessing-ppb\/"},"modified":"2025-12-12T11:36:33","modified_gmt":"2025-12-12T11:36:33","slug":"is-ticlopidine-a-suitable-control-compound-for-assessing-ppb","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/is-ticlopidine-a-suitable-control-compound-for-assessing-ppb\/","title":{"rendered":"Is Ticlopidine a Suitable Control Compound for Assessing PPB?"},"content":{"rendered":"<h2>Plasma protein binding (PPB) is a vital parameter to determine during the drug discovery process, influencing both the pharmacokinetics and pharmacodynamics of a molecule. The major proteins of blood plasma that interact with drugs are human serum albumin (HSA) and \u03b1-acid glycoprotein (AAG), at concentrations of 600 \u00b5M and 12-30 \u00b5M respectively.<\/h2>\n<p>The two major binding sites of HSA show a preference for acidic drugs, and AAG for basic and neutral drugs, with its concentration also influenced by states of disease. Whilst plasma protein binding data alone is not sufficient to base optimisation on, it is required to interpret in vivo data in order to predict drug distribution; only the free drug is available for interaction with the target, and only the free drug is available to be cleared.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover the significance of plasma protein binding (PPB) in drug discovery, influencing pharmacokinetics and pharmacodynamics. Understand HSA and AAG interactions and their impact on drug distribution<\/p>\n","protected":false},"featured_media":2595,"template":"","category":[1],"class_list":["post-3952","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ticlopidine as a Plasma Protein Binding (PPB) Control?<\/title>\n<meta name=\"description\" content=\"Poster assessing ticlopidine as a PPB control compound: human serum albumin and AAG binding, and why only free drug is active. 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