{"id":3930,"date":"2019-03-21T11:44:50","date_gmt":"2019-03-21T11:44:50","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/glutathione-trapping-investigating-the-effects-of-ph-and-glutathione-concentration\/"},"modified":"2025-12-12T11:36:03","modified_gmt":"2025-12-12T11:36:03","slug":"glutathione-trapping-investigating-the-effects-of-ph-and-glutathione-concentration","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/glutathione-trapping-investigating-the-effects-of-ph-and-glutathione-concentration\/","title":{"rendered":"Glutathione Trapping: Investigating the Effects of pH and Glutathione Concentration"},"content":{"rendered":"<p>Some xenobiotics can show idiosyncratic toxicity due to the formation of reactive metabolites. Glutathione (GSH) can be used as a marker for such reactive species by covalently binding to electrophilic sites via the thiol sulphur. Glutathione is known to be acidic so we have investigated the effect of GSH concentration and pH on the formation of GSH adducts and metabolic activity of human liver microsomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Learn how Glutathione (GSH) can serve as a marker for reactive metabolites, impacting xenobiotics&rsquo; toxicity, pH, and metabolic activity in liver microsomes<\/p>\n","protected":false},"featured_media":2562,"template":"","category":[1],"class_list":["post-3930","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigating the Effects of pH and Glutathione Concentration<\/title>\n<meta name=\"description\" content=\"Glutathione can serve as a marker for reactive metabolites, impacting xenobiotics&#039; toxicity, pH, and metabolic activity in liver microsomes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/glutathione-trapping-investigating-the-effects-of-ph-and-glutathione-concentration\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigating the Effects of pH and Glutathione Concentration\" \/>\n<meta property=\"og:description\" content=\"Glutathione can serve as a marker for reactive metabolites, impacting xenobiotics&#039; toxicity, pH, and metabolic activity in liver microsomes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/glutathione-trapping-investigating-the-effects-of-ph-and-glutathione-concentration\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" 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