Abstract<\/p>\n
Generally, microglia exhibit two functionally different activation states in response to insult stimulation,\u00a0termed M1 and M2. The transition from resting microglia to either M1 or M2 activation states results in changes in gene expression levels and key inflammatory cytokines as outlined below (Figure 1).\u00a0Phagocytic activity is also a key feature of microglia, to clear apoptotic cells, protein aggregates as well as\u00a0bacteria from the CNS<\/p>\n
We have characterised a range of relevant in vitro models which include immortalised, primary rodent\u00a0and human iPSC-derived cells to evaluate microglial function. To maximise value from cell-based assays,\u00a0we have adopted a multi-parameter approach which enables a broad range of analyses from individual\u00a0sample wells and may aid progress of microglia-targeted drug discovery projects.We have characterised a range of relevant in vitro models which include immortalised, primary rodent\u00a0and human iPSC-derived cells to evaluate microglial function. To maximise value from cell-based assays,\u00a0we have adopted a multi-parameter approach which enables a broad range of analyses from individual\u00a0sample wells and may aid progress of microglia-targeted drug discovery projects.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2524,"template":"","category":[1],"class_list":["post-3884","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"\n