{"id":3837,"date":"2015-02-24T09:30:25","date_gmt":"2015-02-24T09:30:25","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/fragment-library-design-screening-3\/"},"modified":"2025-12-12T11:34:19","modified_gmt":"2025-12-12T11:34:19","slug":"fragment-library-design-screening-3","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/fragment-library-design-screening-3\/","title":{"rendered":"Fragment Library Design and Screening 3"},"content":{"rendered":"

Abstract<\/p>\n

Fragment-based drug discovery (FBDD) is now a successful approach to hit finding in modern drug discovery. With the approval of Vemurafenib in 2011 and many fragment-derived compounds currently in\u00a0the clinic, FBDD has continued to gain momentum.<\/p>\n

Sygnature Discovery has designed and synthesised a diverse fragment library. The library was designed to\u00a0be readily amenable to medicinal chemists, with each fragment containing at least one point of diversity for\u00a0elaboration. To aid identification of true hits and suggest early SAR the library contains a small number of\u00a0analogues for each fragment.<\/p>\n

The library was assembled predominantly through in-house synthesis and >60%of the fragments are not\u00a0commercially available at the time of publication. The library does not contain any PAINS or reactives. All fragments have been purity checked (>95%purity) using NMR and LCMS.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":2452,"template":"","category":[1],"class_list":["post-3837","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nFragment Library Design and Screening | Poster<\/title>\n<meta name=\"description\" content=\"See how Sygnature designed a diverse fragment library: mostly in-house synthesis, over 60% not commercially available, no PAINS, >95% purity. 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