{"id":22596,"date":"2025-11-16T08:00:12","date_gmt":"2025-11-16T08:00:12","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/plateforme-de-motoneurones-derives-de-cellules-ips-humaines-applications-pour-la-decouverte-de-medicaments-et-la-recherche-sur-la-sla\/"},"modified":"2026-11-12T14:20:51","modified_gmt":"2026-11-12T14:20:51","slug":"plateforme-de-motoneurones-derives-de-cellules-ips-humaines-applications-pour-la-decouverte-de-medicaments-et-la-recherche-sur-la-sla","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/plateforme-de-motoneurones-derives-de-cellules-ips-humaines-applications-pour-la-decouverte-de-medicaments-et-la-recherche-sur-la-sla\/","title":{"rendered":"Plateforme de motoneurones d\u00e9riv\u00e9s de cellules iPS humaines&nbsp;: applications pour la d\u00e9couverte de m\u00e9dicaments et la recherche sur la SLA"},"content":{"rendered":"<p data-start=\"220\" data-end=\"290\"><span style=\"font-family: arial, helvetica, sans-serif;\"><strong data-start=\"220\" data-end=\"290\">Recr\u00e9er la pathologie de la SLA <em>in vitro<\/em> pour d\u00e9couvrir les traitements de demain<\/strong><\/span><\/p>\n<p data-start=\"292\" data-end=\"625\"><span style=\"font-family: arial, helvetica, sans-serif;\">La scl\u00e9rose lat\u00e9rale amyotrophique (SLA) est une maladie neurod\u00e9g\u00e9n\u00e9rative complexe aux options th\u00e9rapeutiques limit\u00e9es et au taux d&rsquo;\u00e9chec clinique \u00e9lev\u00e9. Pour y rem\u00e9dier, nous avons d\u00e9velopp\u00e9, en collaboration avec <a href=\"https:\/\/axolbio.com\/axocells-neurons-and-neuroinflammatory-cells\/axocells-motor-neurons\/\">Axol Bioscience<\/a> , une plateforme de motoneurones d\u00e9riv\u00e9s de cellules souches pluripotentes induites humaines, avec des tests valid\u00e9s pertinents pour la SLA refl\u00e9tant des caract\u00e9ristiques physiopathologiques cl\u00e9s, notamment le dysfonctionnement mitochondrial.<\/span><\/p>\n<p data-start=\"627\" data-end=\"922\"><span style=\"font-family: arial, helvetica, sans-serif;\">Notre plateforme \u00e9volutive permet le criblage \u00e0 haut d\u00e9bit de m\u00e9dicaments et la validation de cibles dans des formats 96 et 384 puits. Nous d\u00e9montrons des diff\u00e9rences ph\u00e9notypiques entre les motoneurones de patients atteints de SLA et ceux de donneurs sains, et nous pr\u00e9sentons des pistes de recherche futures utilisant des facteurs de stress pour mod\u00e9liser la progression de la maladie en plusieurs \u00e9tapes.<\/span><\/p>\n<p data-start=\"924\" data-end=\"1046\"><span style=\"font-family: arial, helvetica, sans-serif;\"><strong data-start=\"924\" data-end=\"1046\"> <\/strong>T\u00e9l\u00e9chargez l&rsquo;affiche pour d\u00e9couvrir comment cette plateforme acc\u00e9l\u00e8re la d\u00e9couverte de m\u00e9dicaments contre la SLA gr\u00e2ce \u00e0 des mod\u00e8les fonctionnels et pertinents pour l&rsquo;humain.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":22598,"template":"","category":[790,814,817,843,1457,818],"class_list":["post-22596","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-criblage-a-haut-debit","category-domaines-therapeutiques","category-essais-cellulaires","category-identification-et-validation-des-cibles","category-neuroscience"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Plateforme de motoneurones d\u00e9riv\u00e9s de cellules iPS humaines pour la SLA | Poster<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez une plateforme d&#039;imagerie \u00e0 haut d\u00e9bit utilisant des fibroblastes de patients pour \u00e9valuer le dysfonctionnement lysosomal dans les maladies d&#039;Alzheimer et de Parkinson.\" 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