{"id":22592,"date":"2025-11-16T08:00:41","date_gmt":"2025-11-16T08:00:41","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/evaluation-de-deux-nouveaux-composes-compares-a-la-methadone-sur-le-sevrage-a-la-morphine-chez-un-modele-de-rat-presentant-une-dependance-physique\/"},"modified":"2026-11-12T14:20:49","modified_gmt":"2026-11-12T14:20:49","slug":"evaluation-de-deux-nouveaux-composes-compares-a-la-methadone-sur-le-sevrage-a-la-morphine-chez-un-modele-de-rat-presentant-une-dependance-physique","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/evaluation-de-deux-nouveaux-composes-compares-a-la-methadone-sur-le-sevrage-a-la-morphine-chez-un-modele-de-rat-presentant-une-dependance-physique\/","title":{"rendered":"\u00c9valuation de deux nouveaux compos\u00e9s compar\u00e9s \u00e0 la m\u00e9thadone sur le sevrage \u00e0 la morphine chez un mod\u00e8le de rat pr\u00e9sentant une d\u00e9pendance physique"},"content":{"rendered":"<p data-start=\"312\" data-end=\"388\"><span style=\"font-family: arial, helvetica, sans-serif;\"><strong data-start=\"312\" data-end=\"388\">Explorer des alternatives plus s\u00fbres \u00e0 la m\u00e9thadone pour le traitement d&rsquo;entretien aux opio\u00efdes<\/strong><\/span><\/p>\n<p data-start=\"390\" data-end=\"664\"><span style=\"font-family: arial, helvetica, sans-serif;\">La m\u00e9thadone demeure un pilier du traitement de substitution aux opio\u00efdes (TSO), mais son utilisation soul\u00e8ve des probl\u00e8mes de s\u00e9curit\u00e9 et d&rsquo;observance. Cette \u00e9tude, men\u00e9e en collaboration avec <a href=\"https:\/\/ensysce.com\/\">Ensysce Biosciences<\/a> , \u00e9value deux nouveaux compos\u00e9s ( <strong data-start=\"594\" data-end=\"615\">PF9110 et PF9201<\/strong> ) dans un <strong data-start=\"621\" data-end=\"663\">mod\u00e8le pr\u00e9clinique de d\u00e9pendance aux opio\u00efdes<\/strong> .<\/span><\/p>\n<p data-start=\"666\" data-end=\"879\"><span style=\"font-family: arial, helvetica, sans-serif;\">Les r\u00e9sultats ? Les deux compos\u00e9s ont att\u00e9nu\u00e9 les principaux sympt\u00f4mes de sevrage <strong data-start=\"729\" data-end=\"771\">sans induire de comportements similaires \u00e0 ceux des opio\u00efdes<\/strong> , soulignant leur potentiel en tant qu&rsquo;alternatives plus s\u00fbres \u00e0 la m\u00e9thadone dans le traitement <strong data-start=\"849\" data-end=\"879\">du trouble li\u00e9 \u00e0 l&rsquo;utilisation d&rsquo;opio\u00efdes (TUO).<\/strong><\/span><\/p>\n<p data-start=\"881\" data-end=\"988\"><span style=\"font-family: arial, helvetica, sans-serif;\">  <strong data-start=\"884\" data-end=\"912\">T\u00e9l\u00e9chargez gratuitement l&rsquo;affiche<\/strong> pour consulter l&rsquo;ensemble des donn\u00e9es et des conclusions de cette \u00e9tude comparative sur un mod\u00e8le de rat.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":22594,"template":"","category":[817,1412,818,816],"class_list":["post-22592","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-domaines-therapeutiques","category-modeles-du-snc-et-de-la-douleur","category-neuroscience","category-pharmacologie-in-vivo"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>PF9110 et PF9201 versus m\u00e9thadone dans le sevrage aux opio\u00efdes<\/title>\n<meta name=\"description\" content=\"Dans cette \u00e9tude men\u00e9e en collaboration avec Ensysce Biosciences, les deux compos\u00e9s ont att\u00e9nu\u00e9 les principaux sympt\u00f4mes de sevrage \u00e0 la morphine chez le rat sans induire de comportements de type opio\u00efde. 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