{"id":22582,"date":"2026-04-03T15:10:34","date_gmt":"2026-04-03T15:10:34","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/une-plateforme-structurale-pour-la-decouverte-de-colles-moleculaires-et-de-protac\/"},"modified":"2026-11-12T14:20:42","modified_gmt":"2026-11-12T14:20:42","slug":"une-plateforme-structurale-pour-la-decouverte-de-colles-moleculaires-et-de-protac","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/une-plateforme-structurale-pour-la-decouverte-de-colles-moleculaires-et-de-protac\/","title":{"rendered":"Une plateforme structurale pour la d\u00e9couverte de colles mol\u00e9culaires et de PROTAC"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-xl-font-size\">De l&rsquo;analyse des fragments \u00e0 la conception des d\u00e9gradeurs, une plateforme CRBN guid\u00e9e par la structure<\/h2>\n\n<p class=\"wp-block-paragraph\">La c\u00e9r\u00e9blon (CRBN) est la ligase E3 la plus utilis\u00e9e pour la d\u00e9gradation cibl\u00e9e des prot\u00e9ines et constitue un \u00e9l\u00e9ment fondamental de la d\u00e9couverte des colles mol\u00e9culaires et des PROTAC. Cependant, l&rsquo;exploration de nouvelles mol\u00e9cules au-del\u00e0 des IMiDs classiques exige des plateformes structurales et biophysiques robustes.<\/p>\n\n<p class=\"wp-block-paragraph\">Dans cette \u00e9tude, nous avons \u00e9tabli une plateforme CRBN <sup>midi<\/sup> recombinante combinant la production de prot\u00e9ines de haute qualit\u00e9 et le criblage de fragments SPR (&gt; Ce flux de travail int\u00e9gr\u00e9 permet l&rsquo;identification et la confirmation structurale de nouveaux ligands du domaine de liaison \u00e0 la thalidomide (TBD), y compris des structures non-imides, gr\u00e2ce \u00e0 l&rsquo;analyse de 2100 compos\u00e9s et \u00e0 la validation par cristallographie aux rayons X.<\/p>\n\n<p class=\"wp-block-paragraph\">R\u00e9sultat\u00a0? Un moteur de d\u00e9couverte \u00e9volutif, bas\u00e9 sur la structure, qui fournit des fragments valid\u00e9s, facilite l\u2019optimisation par la structure et \u00e9largit l\u2019espace chimique accessible aux d\u00e9gradeurs de nouvelle g\u00e9n\u00e9ration.<\/p>\n\n<p class=\"wp-block-paragraph\">\ud83d\udc49 T\u00e9l\u00e9chargez l\u2019affiche gratuite pour d\u00e9couvrir comment cette plateforme acc\u00e9l\u00e8re la d\u00e9couverte de colles mol\u00e9culaires et de PROTAC.<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Criblage de fragments SPR et validation cristallographique des hits avec CRBNmidi<\/p>\n","protected":false},"featured_media":22584,"template":"","category":[790,1410,1416,901,1471,1262,820,815],"class_list":["post-22582","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-caracterisation-des-proteines","category-cristallographie-aux-rayons-x","category-decouverte-de-medicaments-basee-sur-les-fragments","category-degradation-ciblee-des-proteines","category-essais-biophysiques","category-modalites","category-proteines-et-structure"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Plateforme CRBN structurelle pour la d\u00e9couverte de PROTAC | Poster<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez une plateforme CRBN combinant le criblage de fragments SPR et la cristallographie aux rayons X pour identifier et valider des ligands destin\u00e9s \u00e0 la d\u00e9couverte de d\u00e9gradeurs. En savoir plus.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/une-plateforme-structurale-pour-la-decouverte-de-colles-moleculaires-et-de-protac\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une plateforme structurale pour la d\u00e9couverte de colles mol\u00e9culaires et de PROTAC\" \/>\n<meta property=\"og:description\" content=\"D\u00e9couvrez une plateforme CRBN combinant le criblage de fragments SPR et la cristallographie aux rayons X pour identifier et valider des ligands destin\u00e9s \u00e0 la d\u00e9couverte de d\u00e9gradeurs. 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